Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
Oral and Maxillofacial SurgeryUse of amnion as a graft material in vestibuloplasty: a preliminary report☆
Section snippets
Subjects and methods
Seven subjects consisting of 4 women and 3 men (mean age = 63 years) with no known systemic disease who had been referred from the Department of Prosthodontics for mandibular vestibuloplasty took part in this study. The institutional review board of our institution approved this study. Informed consent was obtained before an oral and maxillofacial surgeon began the operation.
Fresh amniotic membrane was provided from healthy seronegative mothers who underwent caesarian section. Small clean
Results
Following the removal of the splint a week after the operation, a white necrotic soft tissue layer could be seen with underlying hyperemic tissue. An average reduction of 1 to 3 mm in the depth of the labial vestibule could be noted (Table I). By the end of the second week, the necrotic layer had disappeared, leaving slightly hyperemic mucosal tissue.
Three of our subjects did not return after the second week. A soft tissue layer similar to attached mucosa with the appropriate consistency was
Discussion
Amniotic membrane has unique properties including antiadhesive effects, bacteriostatic properties, wound protection, pain reduction, and epithelialization effects. Another characteristic of amniotic membrane is the lack of immunogenicity.15 Amniotic membrane has been used as a surgical material for several decades.16
There are only few reports in the literature on reconstruction of oral tissues using amnion. Lawson in 198517 studied the use of amniotic membrane along with pectoralis major muscle
Conclusion
The results generally show that amniotic membrane might be a favorable graft material for vestibuloplasty, promoting healing and preventing relapse. However, further study with larger samples and longer follow-up is certainly recommended.
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This study was supported by the School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.