Osteogenic sarcoma of the jaw bones: A single institution experience over a 21-year period

doi:10.1016/j.tripleo.2005.03.035

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology

Volume 101, Issue 1, January 2006, Pages 76-81

https://doi.org/10.1016/j.tripleo.2005.03.035 Get rights and content

Objective

The purpose of this article is to review cases of osteogenic sarcoma of the jaw bones diagnosed in our institution during a 21-year period.

Study design

Records of patients seen at the Lagos University Teaching Hospital between January 1983 and December 2003 with histologic diagnosis of osteogenic sarcoma were analyzed for age and gender of patients, as well as sites and histologic types of tumor.

Results

Osteogenic sarcoma of the jaws constituted 0.6% of all the biopsies of oral and jaw lesions seen within the period under study. The mean (±SD) age of patients at presentation was 27.2 ± 13.6 years (range 11-70 years). The mean age of patients with maxillary lesions, 30.7 ± 15.8 years (range 17-70 years), was higher than that of patients with mandibular lesions, 23.4 ± 10.1 years (range 11-40 years); however, no statistical significance difference was found (P = .08) There were 12 male and 5 female patients, a ratio of 2.4:1. Nine (53%) tumors were found in the maxilla and 8 (47%) in the mandible, a ratio of 1.1:1. The mandibular lesions were predominant in female patients, while the maxillary lesions were predominant in male patients. The most common histologic subtype was chondroblastic (47%), followed by fibroblastic (35.3%) and osteoblastic types (17.7%).

Conclusion

Osteogenic sarcoma of the jaws is rare in patients who presented with tumor and tumor-like lesions of the jaws in our center, in agreement with previous reports from Africa and other centers around the world. However, the mean age at presentation of our patients was lower than reported in other parts of the world.

Section snippets

Materials and methods

All cases that were histologically diagnosed as osteosarcoma of the jaws from January 1983 to December 2003 were retrieved from the records of the Departments of Oral Pathology and Biology and Oral and Maxillofacial Surgery of the Lagos University Teaching Hospital, Lagos, Nigeria. The histologic slides were reevaluated by one of the authors with a view to classifying the lesions. All the cases were subjected to analysis of age, gender, and symptoms at presentation, as well as site of

Results

Out of 2,830 biopsies of oral and jaw lesions diagnosed between January 1983 and December 2003, 59 (2.08%) were primary malignant bone tumors of the jaws, of which osteosarcoma is the most frequently occurring, accounting for 28.8% (Table I). Other malignant bone tumors of the jaws are as shown on Table I. Of these biopsies of oral and jaw lesions, 17 (0.6%) were osteogenic sarcomas (OS). The mean (±SD) age of patients with OS at presentation was 27.2 ± 13.6 years (range 11-70 years). Five

Discussion

Worldwide, OS is considered to be a rare lesion occurring in about 1 per 100,000 persons per year; about 6% to 7% of all OS occur in the maxillofacial region.4, 14 The incidence of OS is not well established in Nigerians, and few reports from Nigeria are found in the literature.11, 12, 13 OS of the head and neck is considered by most clinicians to be distinct from OS that arises in the long bones. It is reported to affect older patients and follows a different clinical pattern.6, 7, 8, 9, 15, 16

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Oral and Maxillofacial PathologyOsteogenic sarcoma of the jaw bones: A single institution experience over a 21-year period

Objective

Study design

Results

Conclusion

Section snippets

Materials and methods

Results

Discussion

Oral Surg Oral Med Oral Pathol Oral Radiol Endod

Oral Surg Oral Med Oral Pathol Oral Radiol Endod

J Maxillofac Surg

J Oral Maxillofac Surg

Br J Oral Surg

Int J Oral Maxillofac Surg

Int J Oral Maxillofac Surg

Am J Surg

Br J Oral Maxillofac Surg

Oral Surg Oral Med Oral Pathol Oral Radiol Endod

Oral Surg Oral Med Oral Pathol Oral Radiol Endod

Br J Oral Maxillofac Surg

Am J Surg

J Oral Maxillofac Surg

Oral and Maxillofacial Pathology
Osteogenic sarcoma of the jaw bones: A single institution experience over a 21-year period