Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
Oral medicineCorrelation between clinical and histopathologic diagnoses of oral lichen planus based on modified WHO diagnostic criteria
Section snippets
Material and Methods
This study was approved by The Ethics Committee of Research Project in Kerman University of Medical Sciences. The study involved the review of clinical photographs and histological slide specimens.
Microscopic slides and clinical and historical records of patients with oral white lesions were obtained from the files of the Departments of Oral Medicine and Pathology of the Kerman University of Medical Sciences, Iran. Seventy-one microscopic slides were collected by an investigator who did not
Results
Seventy-one pathologic slides were retrieved; clinical photographs were available for 62 of the cases. Pathologic slides consisted of 50 patients with OLP and OLL lesions. Of the 50 slides, 35 (70%) were OLP and 15 (30%) were OLL. Twenty-one cases were other oral white lesions (i.e., 17 cases were leukoplakia and 3 cases were squamous cell carcinoma). Photographs included 47 cases of OLP and 15 cases with other oral white lesions. Of the 71 cases, 41 cases were females and 30 were males. The
Discussion
In this study, the 1978 WHO criteria for the diagnosis of OLP were compared with the modified WHO criteria of 2003. Interobserver and intraobserver variability in clinical and pathologic evaluations were assessed by calculation of unweighted kappa scores. The grading of kappa values were categorized as follows: kappa <0.40 = poor agreement, 0.41< kappa <0.60 = moderate agreement, 0.61< kappa <0.80 = substantial agreement, kappa >0.81 = good agreement.16 Results showed that based on the 1978
References (16)
- et al.
A retrospective survey of oral lichenoid lesions: revisiting the diagnostic process for oral lichen planus
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
(2002) - et al.
Lichenoid lesions of oral mucosa: diagnostic criteria and their importance in the alleged relationship to oral cancer
Oral Surg Oral Med Oral Pathol
(1992) - et al.
Direct oral microscopy and its value in diagnosing mucosal lesions: a pilot study
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
(2000) - et al.
The possible premalignant character of oral lichen planus and oral lichenoid lesions: A prospective study
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
(2003) - et al.
Malignant transformation of oral lichen planus
Oral Oncol
(2003) - et al.
Oral lichen planus: patient profile, disease progression and treatment responses
J Am Dent Assoc
(2001) - et al.
Oral lichen planus and lichenoid reactions: etiopathogenesis, diagnosis, management and malignant transformation
J Oral Sci
(2007) - et al.
Prevalence of oral lichen planus in Brazilian patients with cutaneous lichen planus
Rev Fac Odontol Bauru
(1999)
Cited by (128)
Oral immune-mediated disorders with malignant potential/association: An overview
2023, Disease-a-MonthComputational analysis of histological images from hematoxylin and eosin-stained oral epithelial dysplasia tissue sections
2022, Expert Systems with ApplicationsClinical significance of miR-142-3p in oral lichen planus and its regulatory role in keratinocyte proliferation
2021, Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyCitation Excerpt :The demographic characteristics of the 2 groups are summarized in Table I. The OLP patients were clinically and histologically diagnosed according to the 2003 WHO diagnostic criteria18 by 2 pathologists independently. The inclusion criteria were as follows1: no other dental diseases, no oral mucosal diseases or other infectious diseases, and no history of orthodontic treatment2; not taking antibiotics, immunomodulatory drugs, and other drugs that may affect the immune function in the last 3 months3; and no surgical treatment for oral diseases within 1 year.
This work was supported by Research Center of Kerman Medical Science.