Original articleGrowth factors expression in patients with erosive esophagitis
Section snippets
Patients and procedures
Patients who had the typical GERD symptoms, such as heartburn and acid regurgitation, who were scheduled to receive upper gastrointestinal panendoscopy acted as candidates for this study. The demographic data of patients in term of age, gender, habit of alcohol drinking, smoking, and current medication were recorded. After an overnight fast, each subject first underwent pharyngeal anesthesia with 10% xylocaine (AstraZeneca AB, Sodertalje, Sweden) and then underwent video upper gastrointestinal
Results
Between October 2007 and February 2008, 40 eligible GERD patients with endoscopically proved EE according to LA grade C or D were consequently enrolled. The mean age was 59.5 ± 1.5 years old (range, 38–75 years). Thirty-two (80%) patients were male, and 8 patients (20%) were female.
Discussion
Our study seems to be the first human study to evaluate what kinds of growth factors or their receptors are activated in the injured mucosa of EE. We found that mRNA expressions of HGF, HGFR (c-Met), EGF, VEGF, and COX-2 but not EGFR, KGF, KGFR, bFGF, and COX-1 were significantly increased in the squamous epithelium of EE when compared with those of normal esophageal mucosa.
Although KGF, KGFR, HGF, HGFR, VEGF, COX-2, and ERK signal-transduction pathways are activated and involved in the
Conclusions
Our study showed that HGF, HGFR, EGF, VEGF, and, COX-2 but not KGF, KGFR, EGFR, bFGF, and COX-1 were activated in the injured mucosa of EE patients. We suggested that understanding their activations may provide another therapeutic role in esophageal mucosal repair of EE patients in the future.
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Supported by Grant V97C1-011 from Taipei Veteran General Hospital, Taipei, Taiwan.