Short CommunicationIncreased serum leptin and insulin concentrations in canine hypothyroidism
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Conflict of interest statement
None of the authors of this paper has a financial or personal relationship with other people or organisations that could inappropriately influence or bias the content of the paper.
Acknowledgement
The study was supported by a grant from the Clinical Studies Fund of the Veterinary Teaching Hospital, The Hebrew University of Jerusalem.
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Gestational 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126) exposure disrupts fetoplacental unit: Fetal thyroid-cytokines dysfunction
2018, Life SciencesCitation Excerpt :In general, exposure to persistent organic pollutants (POPs) increase the LEP level [90]. This state might be attributed to reducing the LEP degradation or turnover [91], stimulating the HPTA [22,92], and activating both pregnane-xenobiotic receptor (PXR) and constitutive androstane receptor (CAR) pathways [93]. This elevation may potentially cause insulin resistance and metabolic syndrome with age progress [93,94].
Maternal bisphenol A alters fetal endocrine system: Thyroid adipokine dysfunction
2016, Food and Chemical ToxicologyIncreased serum concentrations of adiponectin in canine hypothyroidism
2015, Veterinary JournalEffects of thyroxin therapy on different analytes related to obesity and inflammation in dogs with hypothyroidism
2013, Veterinary JournalCitation Excerpt :Positive APPs, such as C-reactive protein (CRP), haptoglobin (Hp) and serum amyloid A (SAA) increase their rate of synthesis in the liver and are released into the blood when inflammation occurs (Eckersall, 2000). Some adipocytokines and inflammatory proteins have been studied in human hypothyroidism (Lee et al., 2004; Yu et al., 2006; Kokkinos et al., 2007) but information about canine hypothyroidism is more limited (Dixon et al., 2002; Mazaki-Tovi et al., 2010; Jaillardon et al., 2011). Moreover, to the best of our knowledge, no data have been reported about the possible influence of thyroxin therapy on analytes related to obesity and inflammation in dogs with hypothyroidism.
Impacts of the coexistence of diabetes and hypothyroidism on body weight gain, leptin and various metabolic aspects in albino rats
2012, Journal of Diabetes and its ComplicationsCitation Excerpt :The previous publications in this regard are discordant. Some studies showed a decrease in leptin level in hypothyroidism (Valcavi, Zini, Peino, Casanueva, & Dieguez, 1997; Cettour-Rose et al., 2005) whereas others reported increased (Corbetta et al., 1997; Mazaki-Tovi et al., 2010) or unchanged (Leonhardt, Ritzel, Sch¨afer, Becker, & Ramadori, 1998) levels. With regards to diabetes, the present results are in accordance with Roden et al. (2000) who reported hypoleptinaemia in type 1 and 2 diabetes mellitus.
The potential role of leptin and adiponectin in obesity: A comparative review
2012, Veterinary JournalCitation Excerpt :These findings indicate the importance of obtaining information on the concurrent use of insulin or corticosteroids in dogs before measuring plasma leptin because values may be unreliable. Recently, Mazaki-Tovi et al. (2010) showed that hypothyroid dogs have significantly higher serum leptin concentrations than euthyroid dogs in all BCS classes. In physiological conditions, leptin contributes to the upregulation of thyroid hormones when its concentration lowers and it is therefore possible that in hypothyroidism this mechanism is magnified and leptin concentration increases consequently.