Elsevier

Urology

Volume 65, Issue 2, February 2005, Page 389
Urology

Case report
Bilateral metastatic renal synovial sarcoma

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Abstract

Synovial sarcoma is a malignant soft-tissue neoplasm, usually arising in close association with the joints and generally carrying a poor prognosis. We describe the first report of bilateral renal metastases from synovial sarcoma in a long-term survivor. Treatment consisted of systemic therapy with bilateral partial nephrectomies. The patient was disease free at 1 year of follow-up.

Section snippets

Case report

A 51-year-old woman presented with radiographic findings of bilateral renal masses diagnosed by surveillance computed tomography scans. She was originally diagnosed at age 28 with synovial sarcoma of the left forearm for which she underwent above the elbow amputation. This was followed by multidrug chemotherapy. She developed her first pulmonary metastasis at 5 years postoperatively, experiencing recurrence-free intervals of 2 to 5 years after each serial pulmonary resection. She was again

Comment

Synovial sarcomas account for 6% to 10% of soft-tissue sarcomas, and most of these arise in the extremities. Synovial sarcomas have been known to arise in many diverse tissue types, including the kidney.1, 2 The natural history of this tumor is that of local recurrence. Eventual metastasis is common, with the lungs the most common site, up to 80% in some series, followed by dissemination to the bones and bone marrow.3 We report an uncommon pattern of metastasis involving bilateral renal

References (3)

  • S. Koyama et al.

    Primary synovial sarcoma of the kidneyreport of a case confirmed by molecular detection of the SYT-SSX2 fusion transcripts

    Pathol Int

    (2001)
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