OncologyRisk Factors for Intravesical Recurrence After Surgical Management of Transitional Cell Carcinoma of the Upper Urinary Tract
Section snippets
Material and Methods
A total of 240 patients who were diagnosed as having clinically localized TCC of the upper urinary tract without any suspicious lesions suggesting the presence of metastatic diseases underwent nephroureterectomy at Kobe University Hospital or related hospitals between January 2000 and December 2005. After the exclusion of 63 patients with a history of previous bladder cancer and/or with concurrent bladder cancer, the remaining 177 were included in this study. Of these 177, 111 and 66 underwent
Results
Of the 177 patients included in this study 63 (35.6%) developed recurrent bladder cancer, and the median time to intravesical recurrence after surgery was 7.5 months (range, 2.0 to 51.0 months). Table 1 presents the comparison of clinicopathologic characteristics between patients with and without subsequent intravesical recurrence. The incidence of tumors extending to multiple sites in patients with intravesical recurrence was significantly greater than that in those without intravesical
Comment
The incidence of subsequent bladder cancer after surgical management for upper urinary tract cancer has been shown to be approximately 15% to 50%.1, 2, 3, 4, 5 To date, several studies have identified possible risk factors for subsequent intravesical recurrence after nephrourterectomy2, 3, 4, 5, 6, 7, 8; however, the previously reported risk factors include numerous variables, such as patient age,2 tumor multifocality,2, 5, 7 tumor size,2, 4 pathologic stage,7, 4 tumor grade,3, 8 tumor location,
References (20)
- et al.
Transitional cell carcinoma of the ureter and renal pelvis
Crit Rev Oncol Hematol
(2003) - et al.
Risk factors for subsequent development of bladder cancer after primary transitional cell carcinoma of the upper urinary tract
Urology
(2005) - et al.
Risk factors for the development of bladder cancer after upper tract urothelial cancer
Urology
(2000) - et al.
Laparoscopic radical nephroureterectomy for upper tract transitional cell carcinoma: the Cleveland Clinic experience
J Urol
(2000) - et al.
Retroperitoneoscopic nephroureterectomy for transitional cell carcinoma of the renal pelvis and ureter: Nagoya experience
Urology
(2003) - et al.
Retroperitoneoscopy-assisted total nephroureterectomy for upper urinary tract transitional cell carcinoma
Urology
(2002) - et al.
Oligoclonality in bladder cancer: the implication for molecular therapies
J Urol
(2004) - et al.
Laparoscopic nephroureterectomy for upper urinary tract transitional cell carcinoma: is it better than open surgery?
Eur Urol
(2004) - et al.
Bladder cancer after managing upper urinary tract transitional cell carcinoma: predictive factors and pathology
BJU Int
(2005) - et al.
Bladder tumour development after urothelial carcinoma of the upper urinary tract is related to primary tumour location
BJU Int
(2006)