Surgical Challenges in Radical ProstatectomyRadical Retropubic Prostatectomy for Localized Prostate Cancer in Renal Transplant Patients
Section snippets
Material and Methods
To study the feasibility and necessary technical modifications of RRP in renal transplant recipients, a prospective protocol of surgical treatment for clinically localized prostate cancer was established between August 2004 and November 2007. In that period, 8 patients were found to have prostate cancer. They were screened according to digital rectal examination (DRE) and a total PSA value (chemiluminescence; Diagnostic Products, Los Angeles, CA) with a cut-off value of 2.5 ng/mL. We use the
Results
Eight cancers were diagnosed (6.3%). The indication for biopsy was based on PSA elevation in all but 1 patient, who presented exclusively with abnormal findings on DRE. The preoperative characteristics and pathologic data are summarized in Table 1. Radical retropubic prostatectomy was well tolerated by all patients, and no major complications were observed. The mean age (± standard deviation) at surgery was 59.6 ± 6.7 years (range, 49-67 years). The mean interval between renal transplant and
Comment
In the near future the incidence of prostate cancer in renal transplant patients is expected to increase because of such factors as better survival rates of renal transplant patients and their increasing age at transplantation.1, 4 Most patients (84%) with prostate cancer detected after solid organ transplantation are diagnosed with localized disease.17 There is controversy regarding the ideal treatment modality for localized prostate cancer in the general (non-transplant) population, and the
Conclusions
In renal transplant recipients with localized prostate cancer, curative treatment should be offered despite the fact that there is no consensus about the best treatment modality in this setting. Kidney transplantation does not interfere with surgical access to the prostate gland. Radical retropubic prostatectomy in renal transplant patients is safe and can be used to effectively treat localized prostate cancer achieving equivalent results to non transplant patients. The only technical
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Cited by (23)
Urologic malignancies in renal transplant candidates and recipients
2016, Progres en UrologieRobot-Assisted Radical Prostatectomy for Localized Prostate Cancer in Asian Renal Transplant Recipients
2016, Transplantation ProceedingsEfficacy and Feasibility of Low-Dose Rate Brachytherapy for Prostate Cancer in Renal Transplant Recipients
2016, Transplantation ProceedingsCitation Excerpt :The other half of the patients were given only androgen deprivation therapy (data not shown). Recently, there have been several reports about radical prostatectomy for RTRs, including robot-assisted radical prostatectomy or laparoscopic radical prostatectomy [7–18]. Most authors have concluded that radical prostatectomy is feasible and acceptable, even for RTRs.
Efficacy and Feasibility of Intensity-Modulated Radiation Therapy for Prostate Cancer in Renal Transplant Recipients
2016, Transplantation ProceedingsDevelopment of urologic de novo malignancies after renal transplantation
2014, Transplantation ProceedingsCitation Excerpt :Radical prostatectomy is safe, effective, and can be performed in transplanted patients. The surgical approaches used are the classic retropubic [19], the pure laparoscopic [20], or robot-assisted laparoscopic [21]. They all have shown similarities in safety and oncologic outcomes, although the newer techniques have a logical lack of long-term follow-up.