Elsevier

Virology

Volume 446, Issues 1–2, November 2013, Pages 346-348
Virology

Brief Communication
Divergent gyroviruses in the feces of Tunisian children

https://doi.org/10.1016/j.virol.2013.08.020Get rights and content
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Highlights

  • We report two new gyrovirus species in diarrheic samples from Tunisian children.

  • The genetic analyses of these divergent gyroviruses are described.

  • Gyroviruses can be classified into two groups with significant genomic differences.

Abstract

The Gyrovirus genus consists of the immunosuppressive Chicken Anemia Virus (CAV) prototype and since 2011 three other viral species found in sera/tissues of chickens, human feces, and on human skin. Here the genomes of two other gyrovirus species were characterized in diarrhea samples from Tunisian children whose main ORFs shared amino acid identity of 46–59% with those of the previously characterized gyroviruses and were provisionally named GyV5 and GyV6. All currently known gyroviruses grouped into two clades with distinct genomic features including replacement of the VP2 overlapping Apoptin gene with a distinct ORF of unknown function. Previous reports of gyrovirus DNA in human blood and on human skins warrant studies of possible human tropisms for these newly characterized gyroviruses.

Keywords

Gyrovirus
Diarrhea
Feces
Children

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