F gene recombination between genotype II and VII Newcastle disease virus

doi:10.1016/j.virusres.2007.10.001

Virus Research

Volume 131, Issue 2, February 2008, Pages 299-303

https://doi.org/10.1016/j.virusres.2007.10.001 Get rights and content

Abstract

A velogenic Newcastle disease virus (NDV) strain, designated as SRZ03, was isolated from an egg layer flock with NDV vaccine immunization failure in China in 2003. Recombination was found in the F gene of SRZ03. Complete genome sequences analysis indicated that the N-terminal of SRZ03 F gene originated from a genotype II NDV strain, whereas the C-terminal of F gene and the rest of the genes originated from a prevalent velogenic genotype VII NDV strain. It provides us valuable information for understanding the recombination of nonsegmented negative-sense RNA viruses.

Section snippets

Acknowledgements

This study was funded by Project for Science and Technology Development of Shandong Province (030317), the Ministry of Science and Technology of China program (2006BAD06A04), National Basic Research Program (973 Program) of China (2005CB523002), Natural Science Foundation of Shandong Province (031020101) and Hundreds of Talents Program of Chinese Academy of Sciences. We thank Shandong Agriculture University for invaluable contributions for this study. We also thank Huai-ying Xu, Ye-feng He and

References (28)

A.M. Archer et al.
High genetic divergence and recombination in Arenaviruses from the Americas
Virology
(2002)
R.N. Charrel et al.
The Whitewater Arroyo virus: natural evidence for genetic recombination among Tacaribe serocomplex viruses (family Arenaviridae)
Virology
(2001)
H.J. Kwon et al.
Molecular epidemiology of Newcastle disease in Republic of Korea
Vet. Microbiol.
(2003)
H. Liu et al.
Molecular epidemiological analysis of Newcastle disease virus isolated in China in 2005
J. Virol. Methods
(2007)
Y. Shengqing et al.
Generation of velogenic Newcastle disease viruses from a nonpathogenic waterfowl isolate by passaging in chickens
Virology
(2002)
D.J. Alexander
Newcastle disease
D.J. Alexander
Newcastle disease and other paramyxovirus infections
A. Ballagi-Pordany et al.
Identification and grouping of Newcastle disease virus strains by restriction site analysis of a region from the F gene
Arch. Virol.
(1996)
C.W. Beard et al.
Newcastle disease
E.R. Chare et al.
Phylogenetic analysis reveals a low rate of homologous recombination in negative-sense RNA viruses
J. Gen. Virol.
(2003)

M.S. Collins et al.

Evaluation of the molecular basis of pathogenicity of the variant Newcastle disease viruses termed “pigeon PMV-1 viruses”

Arch. Virol.

(1994)

E. Domingo et al.

RNA virus mutations and fitness for survival

Annu. Rev. Microbiol.

(1997)

M.J. Gibbs et al.

Recombination in the hemagglutinin gene of the 1918 “Spanish flu”

Science

(2001)

J. Herczeg et al.

Two novel genetic groups (VIIb and VIII) responsible for recent Newcastle disease outbreaks in Southern Africa, one (VIIb) of which reached Southern Europe

Arch. Virol.

(1999)

Cited by (61)

Updated unified phylogenetic classification system and revised nomenclature for Newcastle disease virus
2019, Infection, Genetics and Evolution
Several Avian paramyxoviruses 1 (synonymous with Newcastle disease virus or NDV, used hereafter) classification systems have been proposed for strain identification and differentiation. These systems pioneered classification efforts; however, they were based on different approaches and lacked objective criteria for the differentiation of isolates. These differences have created discrepancies among systems, rendering discussions and comparisons across studies difficult. Although a system that used objective classification criteria was proposed by Diel and co-workers in 2012, the ample worldwide circulation and constant evolution of NDV, and utilization of only some of the criteria, led to identical naming and/or incorrect assigning of new sub/genotypes. To address these issues, an international consortium of experts was convened to undertake in-depth analyses of NDV genetic diversity. This consortium generated curated, up-to-date, complete fusion gene class I and class II datasets of all known NDV for public use, performed comprehensive phylogenetic neighbor-Joining, maximum-likelihood, Bayesian and nucleotide distance analyses, and compared these inference methods. An updated NDV classification and nomenclature system that incorporates phylogenetic topology, genetic distances, branch support, and epidemiological independence was developed. This new consensus system maintains two NDV classes and existing genotypes, identifies three new class II genotypes, and reduces the number of sub-genotypes. In order to track the ancestry of viruses, a dichotomous naming system for designating sub-genotypes was introduced. In addition, a pilot dataset and sub-trees rooting guidelines for rapid preliminary genotype identification of new isolates are provided. Guidelines for sequence dataset curation and phylogenetic inference, and a detailed comparison between the updated and previous systems are included. To increase the speed of phylogenetic inference and ensure consistency between laboratories, detailed guidelines for the use of a supercomputer are also provided. The proposed unified classification system will facilitate future studies of NDV evolution and epidemiology, and comparison of results obtained across the world.
A genotype VII Newcastle disease virus-like particles confer full protection with reduced virus load and decreased virus shedding
2019, Vaccine
Newcastle disease (ND) is one of the most severe avian infectious disease inflicting a great loss on poultry industry worldwide. The control of ND relies on proper vaccination strategies. The vaccine strains of Newcastle disease virus (NDV) mainly belong to genotype I, II or III, which cannot fully prohibit virus shedding against the prevalent genotype VII virulent strain attack. To develop a safe, genotype matched vaccine candidate, we employed a bac-to-bac expression system and constructed a genotype VII NDV strain based virus-like particles (NDV VLPs). It was constructed with NDV M protein as the skeleton, and protective antigen F and HN proteins displayed on the surface. The NDV VLPs exhibited a similar appearance to the live NDV particles, but with denser F and HN proteins displayed on the surface. The immunization assay indicated that NDV VLPs stimulated a longer protection period, less tissue virus loading and shorter virus shedding period than the commercialized LaSota-formulated vaccine when challenged with genotype VII NDV strain. These results proposed the potential role of NDV VLPs as an alternative to current live genotype unmatched vaccine for the control and eliminate NDV in the avian flocks.
Comparative evolutionary and phylogenomic analysis of Avian avulaviruses 1–20
2018, Molecular Phylogenetics and Evolution
Avian avulaviruses (avulaviruses or AAvVs) infect a wide range of avian species worldwide with variable clinical outcomes and economic impacts. Owing to broad host spectrum, several novel avulaviruses are being reported from both wild and domesticated birds that highlight the potential of the virus to evolve, adapt and emerge in susceptible population. Pathobiological and phylogenetic characterizations of individual avulaviruses are often demonstrated, however, a cumulative and comparative assessment of avulaviruses remains elusive. To assess evolutionary dynamics and potential emergence of novel avulaviruses, we enriched existing databases of all known avulaviruses (specie-type 1–20), and determined their genomics features based on both complete genomes and individual complete genes. While a high nucleotide divergence (up to 65.4%) was observed among avulaviruses, phylogenomic analysis revealed clustering of all avulaviruses into three distinct clades. The major clade (Clade-I) included both oldest and newest avulaviruses (2, 5, 6, 7, 8, 10, 11, 14, 15 and 20) and the second clade (Clade-II) consisted of avulaviruses 1, 9, 12, 13, 16, 17, 18 and 19, whereas the third clade (Clade-III) carried only avulaviruses 3 and 4. Intriguingly, clustering pattern was descriptive for individual gene-based analysis, however, the hemagglutinin-neuraminidase (HN) and polymerase (L) genes showed clear and discrete branching patterns similar to complete genome-based clustering. Therefore, we propose the use of HN, or L genes or complete genome to study epidemiological aspects of the avulaviruses. Genomic and residue characteristics of all genes indicated a continuous evolution of the virus, and substitutions in biologically important motifs warrant future investigations to assess their roles in the pathobiology of the virus. Taken together, this comprehensive analysis of all known avulaviruses ascertains continuous monitoring and surveillance of wild/water-fowls and commercial poultry. These findings further our understanding on the evolutionary dynamics and potential emergence of novel avulaviruses and will establish bases to identify potential of wild-bird origin apathogenic viruses to cause infections in commercial poultry.
Spillover of Newcastle disease viruses from poultry to wild birds in Guangdong province, southern China
2017, Infection, Genetics and Evolution
Despite intensive vaccination programs in many countries, including China, Newcastle disease has been reported sporadically and is still a significant threat to the poultry industry in China. Newcastle disease virus (NDV) is infectious for at least 250 bird species, but the role of wild birds in virus epidemiology remains largely unknown. Fourteen NDV isolates were obtained from 2040 samples collected from wild birds or the environment in Guangdong province, southern China, from 2013 to 2015. The isolation rate was the highest in the period of wintering and lowest during the periods of spring migration, nesting, and postnesting. A maximum clade credibility phylogenetic analysis revealed that at least four genotypes circulate in southern China: three class II genotypes (II, VI, and IX) and one class I (1b). We also demonstrated that most isolates from wild birds were highly similar to isolates from poultry, and two isolates were linked to viruses from wild birds in northern China. These data suggested that wild birds could disseminate NDV and poultry-derived viruses may spillover to wild birds. Accordingly, vaccine development and poultry management strategies should be considered to prevent future NDV outbreaks, particularly given the strength of the poultry industry in developing countries, such as China.
Reciprocal complementation of bovine parainfluenza virus type 3 lacking either the membrane or fusion gene
2017, Journal of Virological Methods
Two defective bovine parainfluenza virus type 3 (BPIV3) strains were generated, one lacking the membrane (M) protein gene and expressing EGFP (ΔM-EGFP) and the other lacking the fusion (F) protein gene and expressing mStrawberry (ΔF-mSB), by supplying deficient proteins in trans. When Madin-Darby bovine kidney (MDBK) cells were co-infected with ΔM-EGFP and ΔF-mSB at a multiplicity of infection (MOI) of 0.1, complemented viruses were easily obtained. Complemented viruses grew as efficiently as wild-type BPIV3 and could be passaged in MDBK cell cultures even at an MOI of 0.01, possibly due to multiploid virus particles containing genomes of both ΔM-EGFP and ΔF-mSB. This reciprocal complementation method using two defective viruses would be useful to express large or multiple proteins in cell cultures using paramyxovirus vectors.
Characterization of Gene Coding Fusion Protein of Newcastle Disease Virus Infected in Native Chicken in Surabaya
2022, Jurnal Medik Veteriner

View all citing articles on Scopus

¹: These authors contributed equally to this work.

View full text

Article preview

Virus Research

Abstract

Section snippets

Acknowledgements

References (28)

High genetic divergence and recombination in Arenaviruses from the Americas

Virology

The Whitewater Arroyo virus: natural evidence for genetic recombination among Tacaribe serocomplex viruses (family Arenaviridae)

Virology

Molecular epidemiology of Newcastle disease in Republic of Korea

Vet. Microbiol.

Molecular epidemiological analysis of Newcastle disease virus isolated in China in 2005

J. Virol. Methods

Generation of velogenic Newcastle disease viruses from a nonpathogenic waterfowl isolate by passaging in chickens

Virology

Newcastle disease

Newcastle disease and other paramyxovirus infections

Identification and grouping of Newcastle disease virus strains by restriction site analysis of a region from the F gene

Arch. Virol.

Newcastle disease

Phylogenetic analysis reveals a low rate of homologous recombination in negative-sense RNA viruses

J. Gen. Virol.

Evaluation of the molecular basis of pathogenicity of the variant Newcastle disease viruses termed “pigeon PMV-1 viruses”

Arch. Virol.

RNA virus mutations and fitness for survival

Annu. Rev. Microbiol.

Recombination in the hemagglutinin gene of the 1918 “Spanish flu”

Science

Two novel genetic groups (VIIb and VIII) responsible for recent Newcastle disease outbreaks in Southern Africa, one (VIIb) of which reached Southern Europe

Arch. Virol.

Cited by (61)

Updated unified phylogenetic classification system and revised nomenclature for Newcastle disease virus

A genotype VII Newcastle disease virus-like particles confer full protection with reduced virus load and decreased virus shedding

Comparative evolutionary and phylogenomic analysis of Avian avulaviruses 1–20

Spillover of Newcastle disease viruses from poultry to wild birds in Guangdong province, southern China

Reciprocal complementation of bovine parainfluenza virus type 3 lacking either the membrane or fusion gene

Characterization of Gene Coding Fusion Protein of Newcastle Disease Virus Infected in Native Chicken in Surabaya

Short communicationF gene recombination between genotype II and VII Newcastle disease virus

Abstract

Section snippets

Acknowledgements

Virology

Virology

Vet. Microbiol.

J. Virol. Methods

Virology

Newcastle disease

Newcastle disease and other paramyxovirus infections

Identification and grouping of Newcastle disease virus strains by restriction site analysis of a region from the F gene

Arch. Virol.

Newcastle disease

Phylogenetic analysis reveals a low rate of homologous recombination in negative-sense RNA viruses

J. Gen. Virol.

Evaluation of the molecular basis of pathogenicity of the variant Newcastle disease viruses termed “pigeon PMV-1 viruses”

Arch. Virol.

RNA virus mutations and fitness for survival

Annu. Rev. Microbiol.

Recombination in the hemagglutinin gene of the 1918 “Spanish flu”

Science

Two novel genetic groups (VIIb and VIII) responsible for recent Newcastle disease outbreaks in Southern Africa, one (VIIb) of which reached Southern Europe

Arch. Virol.

Short communication
F gene recombination between genotype II and VII Newcastle disease virus