Elsevier

Developmental Biology

Volume 373, Issue 2, 15 January 2013, Pages 235-243
Developmental Biology

Review
Role of kruppel-like transcription factors in adipogenesis

https://doi.org/10.1016/j.ydbio.2012.10.031Get rights and content
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Abstract

The zinc-finger transcription factors of the kruppel-like factor family (KLF) are critical in many physiological and pathological processes including cell proliferation, differentiation, inflammation, and apoptosis. Recently, there is increasing evidence that suggests these KLFs have an important role in fat biology. This review summarizes the role of KLFs in lipid metabolism, especially in adipogenesis, and reveals the relationship networks among members of KLF family in differentiation.

Highlights

► KLF4 stimulates adipogenesis by activating C/EBPβ with Krox20. ► KLF6 promotes preadipocyte differentiation through HDAC3 inhibition of Dlk1. ► KLF5, KLF9, and KLF15 stimulate adipocyte differentiation via transactivating PPARγ. ► KLF2 inhibits PPARγ, whereas KLF3 represses C/EBPα and CtBP during adipogenesis. ► KLF7 inhibits adipogenesis by decreasing the expression of both PPARγ and C/EBPα.

Keywords

Kruppel-like factor
Adipocyte
Adipogenesis
Transcription

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