Elsevier

Genomics

Volume 108, Issues 5–6, December 2016, Pages 194-200
Genomics

Correlations of VDR and VDBP genetic polymorphisms with susceptibility to adolescent idiopathic scoliosis and efficacy of brace treatment

https://doi.org/10.1016/j.ygeno.2016.11.004Get rights and content
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Highlights

  • The frequency of Bsm I Bb and B in the AIS group was higher than the control group.

  • The frequency of rs222020 GG and G in the AIS group was higher than the control group.

  • The failure rate of brace treatment in Bsm I Bb was higher than that in the BB or bb.

  • The failure rate of rs222020 CC was higher than that of the CT or TT.

  • VDR Bsm I Bb and VDBP rs222020 CC are related to AIS and brace efficacy.

Abstract

Objective

This paper aimed to elucidate the correlations of VDR and VDBP polymorphisms with susceptibility to adolescent idiopathic scoliosis (AIS) and efficacy of brace treatment.

Methods

AIS patients and healthy controls were enrolled. Lumbar spine bone mineral density (LSBMD) and femoral neck bone mineral density (FNBMD) were detected by dual energy X-ray absorptiometry. VDR and VDBP polymorphisms were detected by PCR-RFLP. Efficacy of brace treatment was evaluated by Cobb measurement.

Results

The frequencies of Bsm I Bb genotype and B allele, and rs222020 CC genotype and C allele in the AIS patients were higher than in the controls. After treatment, the correction rates of average Cobb angle, AVT, AVR and TS in patients with Bsm I Bb and VDBP rs222020 CC genotypes were relatively low.

Conclusion

VDR Bsm I and VDBP rs222020 C > T polymorphisms may be predisposition factors of AIS and the efficacy of brace treatment in AIS patients.

Keywords

VDR
VDBP
Adolescent idiopathic scoliosis
Brace treatment
Efficacy
Polymorphism

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