A prospective, randomized, double-blind multicenter comparison of parenteral ertapenem and ceftriaxone for the treatment of hospitalized adults with community-acquired pneumonia
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Clostridium difficile infection following systemic antibiotic administration in randomised controlled trials: a systematic review and meta-analysis
2016, International Journal of Antimicrobial AgentsHigher than expected rates of seizures associated with the use of ertapenem in older hospitalized patients
2013, Journal of Clinical Gerontology and GeriatricsCitation Excerpt :Of these, 14 are randomized controlled trials with active comparator arms, while two included open-label experiences in treating ventilator-associated pneumonia.28,29 Of the nearly 3000 patients who received a single dose of 1 g or more of ertapenem, only three drug-related seizures were reported.16,21,22 Several other case reports show an incidence rate of up to 0.5% in adults.30–35
Guidelines for the management of adult lower respiratory tract infections - Summary
2011, Clinical Microbiology and InfectionCitation Excerpt :Penicillin G ± macrolide dIn patients at risk of gram-negative enteric bacterium, particularly strains with extended-spectrum β-lactamase, but without risk (or after exclusion) of P. aeruginosa, ertapenem may be used [100,158,274–304]. Treatment options for patients with severe community-acquired pneumonia [C4] (ICU or intermediate care).
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Members of the Protocol 020 Study Group are listed in the Acknowledgments.