Research paperIsolation, characterization and geographic distribution of Caño Delgadito virus, a newly discovered South American hantavirus (family Bunyaviridae)
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2017, Antiviral ResearchCitation Excerpt :Hantaviruses are notoriously difficult to isolate from the reservoir hosts or diseased humans, and often require multiple blind passages in cell culture to obtain sufficiently high titers for further characterization and experimentation. Interestingly, propagation in cell culture may result in loss of the ability to reliably infect their natural reservoirs (Fulhorst et al., 1997). An example is provided by Puumala virus (PUUV), an etiological agent of a mild form of HFRS commonly referred to as nephropathia epidemica (NE), which is carried by the bank vole (Clethrionomys glareolus) (Lähdevirta et al., 1984).
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2014, Virus ResearchCitation Excerpt :In 1997, a hantavirus was isolated from a Sigmodon alstoni rodent captured in the plains of Venezuela. The serology and the nucleotide-sequence analysis showed it was a novel hantavirus which was named Caño Delgadito (Fulhorst et al., 1997). However, it is not known if this hantavirus is associated with HCPS.
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2011, Advances in Applied MicrobiologyCitation Excerpt :However, the etiologic agent and rodent reservoir of HCPS, the Sin Nombre virus (SNV), were discovered within few weeks after the 1993s outbreak in the Four Corners region of the United States (Hjelle et al., 1994; Nichol et al., 1993). After this outbreak, other hantavirus strains causing HCPS were discovered and more than 2000 cases of HCPS have been reported throughout the Americas (Aquino et al., 2003; Barclay and Rubinstein, 1997; Bayard et al., 2004; Bohlman et al., 2002; Chu et al., 2006; Fulhorst et al., 1997; Hjelle et al., 1994, 1996; Jiang et al., 1997; Johnson et al., 1997; Jones et al., 2008; Nichol et al., 1993; Vincent et al., 2000). Currently, the hantavirus genus includes more than 21 species and more than 30 genotypes (Avsic-Zupanc et al., 2000; Chu et al., 2006), although many more remain undiscovered due to the lack of advanced technology in other parts of the world including Africa, Middle East, and the Indian subcontinent.
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