ArticleMicrochimeric fetal cells cluster at sites of tissue injury in lung decades after pregnancy
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Keelin O'Donoghue is a medical graduate of University College Dublin and a member of the Royal College of Obstetrics and Gynaecologists. She received her PhD in Obstetrics and Gynaecology on fetomaternal stem cell trafficking from the University of London. Having completed sub-specialization in Maternal and Fetal Medicine at Queen Charlotte's Hospital London in 2007, she has recently taken up a post as Consultant Obstetrician/Gynaecologist and Senior Lecturer at Cork University Maternity
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2022, Developmental CellFeto-maternal microchimerism: Memories from pregnancy
2022, iScienceCitation Excerpt :FMc may have conflicting roles, not mutually exclusive. These functions could be beneficial, harmful, or neutral for maternal pathophysiology (O’Donoghue et al., 2008). On the one hand, FMc may have a beneficial (protective and regenerative) role in maternal health, participating in tissue repair and regeneration, cell replacement, and maternal homeostatic maintenance (Boddy et al., 2015).
Circulating tumor stem cells and glioblastoma: A review
2019, Journal of Clinical NeuroscienceCitation Excerpt :We therefore suggest that GB CTSCs display similar plasticity between the epithelial and mesenchymal states and can enter and exit the vasculature and persist within a patient’s circulation, independent of the primary tumor. Fetal cells transferred into maternal circulation during pregnancy can persist for decades and there is evidence indicating that stem cells are the source of this micro-chimerism [59]. There are a number of GB microenvironments which are conducive to stimulating EMT, including generating hypoxic conditions which recruit macrophages to the tumor stroma [52].
Keelin O'Donoghue is a medical graduate of University College Dublin and a member of the Royal College of Obstetrics and Gynaecologists. She received her PhD in Obstetrics and Gynaecology on fetomaternal stem cell trafficking from the University of London. Having completed sub-specialization in Maternal and Fetal Medicine at Queen Charlotte's Hospital London in 2007, she has recently taken up a post as Consultant Obstetrician/Gynaecologist and Senior Lecturer at Cork University Maternity Hospital and University College Cork. Her research interests include non-invasive prenatal diagnosis, fetal microchimerism, stem cell biology, and monochorionic twin pregnancy.
Declaration: Nicholas Fisk is a consultant to Omnicyte Ltd and a director of RevealCyte Ltd. The other authors report no financial or commercial conflicts of interest.