Hostname: page-component-848d4c4894-x24gv Total loading time: 0 Render date: 2024-06-04T22:40:46.131Z Has data issue: false hasContentIssue false
  • English
  • Français

Schizophrenia and Cushing's syndrome cured by adrenalectomy

Published online by Cambridge University Press:  09 July 2009

John Johnson
John Johnson
Affiliation:
Department of Psychiatry, Manchester Royal Infirmary, Manchester
Get access Rights & Permissions [Opens in a new window]

Synopsis

A case of Cushing's syndrome in a woman aged 50 years is described, with psychosis of schizophrenic type. The psychosis and endocrine disorder were subsequently cured by adrenalectomy. Twenty-five years previously the patient had a typical schizophrenic psychosis treated in mental hospital with deep insulin therapy and ECT. The possibility is raised that deep insulin therapy could have induced the Cushing's syndrome through its non-specific stressor effect on the pituitary-adrenal axis.

Type
Original Article
Information
Psychological Medicine , Volume 5 , Issue 2 , May 1975 , pp. 165 - 168
Copyright
Copyright © Cambridge University Press 1975

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Allen, C. (1939). Paranoid psychosis with adrenogenital virilism successfully treated by adrenalectomy. British Medical Journal, 1, 1220–1224.CrossRefGoogle Scholar
Allen, C., and Broster, L. R. (1945). A further case of paranoid psychosis successfully treated by adrenalectomy. British Medical Journal, 1, 696–698.CrossRefGoogle Scholar
Bleuler, M. (1951). The psychopathology of acromegaly. Journal of Nervous and Mental Disease, 113, 497–511.Google ScholarPubMed
Bleuler, M. (1954). Endokrinologische Psychiatric. Thieme: Stuttgart.Google Scholar
Bleuler, M. (1964). Endokrinologische Psychiatric Psychiatrie der Gegenwart, Band 1, Teil B. Edited by Gruhle, H. W., Jung, R., Mayer-Gross, W., and Müller, M.. Springer: Berlin.Google Scholar
Bliss, E. L., Migeon, C. J., Nelson, D. H., Samuels, L. T., and Branch, C. H. H. (1954). Influence of E.C.T. and insulin coma on level of adrenocortical steroids in peripheral circulation. Archives of Neurology and Psychiatry, 72, 352–361.CrossRefGoogle ScholarPubMed
Burke, C. W. (1973). The Adrenal Cortex in Practical Medicine. Gray-Mills: London.Google Scholar
Clark, L. D., Bauer, W., and Cobb, S. (1952). Preliminary observations on mental disturbances occurring in patients under treatment with cortisone and ACTH. New England Journal of Medicine, 246, 205–216.CrossRefGoogle Scholar
Granville-Grossman, K. L. (1971). Recent Advances in Clinical Psychiatry. Churchill: London.Google Scholar
Hamm, F. C. (1955). Adrenal surgery for psychoses associated with Cushing's syndrome. Archives of Surgery, 71, 617–619.CrossRefGoogle ScholarPubMed
Hamilton, J. A. (1962). Postpartum Psychiatric Problems. Mosby: St. Louis.Google Scholar
Hertz, P. E., Nadas, E., and Wojtkowski, H. (1955). Cushing's syndrome and its management. American Journal of Psychiatry, 112, 144–145.CrossRefGoogle ScholarPubMed
Hickman, J. W., Atkinson, R. P., Flint, D. L., and Hurxthal, L. M. (1961). Transient schizophrenic reaction as a major symptom of Cushing's syndrome. New England Journal of Medicine, 264, 797–800.CrossRefGoogle Scholar
Kalinowsky, L. B., and Hippius, H. (1969). Pharmacological, Convulsive, and other Somatic Treatments in Psychiatry. Grune and Stratton: New York.Google Scholar
Kay, W. W. (1961). The treatment of prolonged insulin coma. Journal of Mental Science, 107, 194–238.CrossRefGoogle ScholarPubMed
Landon, J., and James, J. H. T. (1972). Biochemical test procedures in the investigation of Cushing's syndrome. In Cushing's Syndrome, pp. 35–44. Edited by Binder, C. and Hall, P. E.. Heinemann: London.Google Scholar
Maclay, W. S., and Stokes, A. B. (1938). Mental disorder in Cushing's syndrome. Journal of Neurology, Neurosurgery and Psychiatry, 1, 110–119.CrossRefGoogle ScholarPubMed
Michael, R. P., and Gibbons, J. L. (1963). Interrelationships between the endocrine system and neuropsychiatry. International Review of Neurobiology, 5, 243–302.CrossRefGoogle Scholar
Quarton, G. C., Clark, L. D., Cobb, S., and Bauer, W. (1955). Mental disturbances associated with ACTH and cortisone. Medicine, 34, 13–50.CrossRefGoogle Scholar
Regestein, Q. R., Rose, L. I., and Williams, G. H. (1972). Psychopathology in Cushing's syndrome. Archives of Internal Medicine, 130, 114–117.CrossRefGoogle ScholarPubMed
Schneider, K. (1959). Clinical Psychopathology. Translated by Hamilton, M. W.. Grune and Stratton: New York.Google Scholar
Trethowan, W. H., and Cobb, S. (1952). Neuropsychiatric aspects of Cushing's syndrome. Archives of Neurology and Psychiatry, 67, 283–309.CrossRefGoogle ScholarPubMed