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Hypervolemic-Hemodilution and Hypertension During Temporary Middle Cerebral Artery Occlusion in Rats: The Effect on Blood-Brain Barrier Permeability

Published online by Cambridge University Press:  18 September 2015

Daniel J. Cole ,
John C. Drummond ,
Jerry S. Matsumura ,
Suzzanne Marcantonio  and
Bonnie I. Chi-Lum
Daniel J. Cole*
Affiliation:
Department of Anesthesiology, Loma Linda University, Loma Linda
John C. Drummond
Affiliation:
Veteran's Administration Medical Center, San Diego University of California at San Diego, La Jolla, California
Jerry S. Matsumura
Affiliation:
Department of Anesthesiology, Loma Linda University, Loma Linda
Suzzanne Marcantonio
Affiliation:
Department of Anesthesiology, Loma Linda University, Loma Linda
Bonnie I. Chi-Lum
Affiliation:
Department of Anesthesiology, Loma Linda University, Loma Linda
*
Department of Anesthesiology, Loma Linda University, Loma Linda, California 92354, U.S.A.
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Abstract:

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The effect of hypervolemic-hemodilution, with and without hypertension, on blood-brain barrier permeability was investigated in rats, after 180 minutes of middle cerebral artery occlusion (MCAo), and 60 minutes of reperfusion. One of the following conditions was maintained during MCAo: 1) Control — hematocrit and blood pressure were not manipulated; 2) Hypervolemic-Hemodilution/Normotension — the hematocrit was decreased to 30%; 3) Hypervolemic-Hemodilution/Hypertension — the hematocrit was decreased to 30% and mean arterial pressure increased by 30 mmHg with phenylphrine. In all groups, Evans Blue was administered, and its concentration determined by spectrophotometric assay. Evans Blue (μg{g-1 of brain tissue [mean ± SD]) was greater in the Hypervolemic- Hemodilution/Hypertension group (71 ± 20) versus the Control (13 ± 9) and Hypervolemic-Hemodilution/ Normotension (17 ± 10) groups (p < 0.05). No other differences were present. These results support the hypothesis that during MCAo, hypervolemic-hemodilution/hypertensive therapy effects an increase in blood-brain barrier permeability in the early period of reperfusion.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 17 , Issue 4 , November 1990 , pp. 372 - 377
Copyright
Copyright © Canadian Neurological Sciences Federation 1990

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