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Haemagglutination-inhibition antibodies against influenza A and influenza B in maternal and neonatal sera

Published online by Cambridge University Press:  15 May 2009

N. Masurel ,
J. I. de Bruijne ,
H. A. Beuningh  and
H. J. A. Schouten
N. Masurel
Affiliation:
Department of Virology and WHO Influenza Centre, Erasmus University Rotterdam, Rotterdam, The Netherlands
J. I. de Bruijne
Affiliation:
Department of Neonatology, University of Amsterdam, Amsterdam, The Netherlands
H. A. Beuningh
Affiliation:
Department of Obstetrics and Gynaecology, University of Amsterdam, Amsterdam, The Netherlands
H. J. A. Schouten
Affiliation:
Institute for Biostatistics, Erasmus University Rotterdam, Rotterdam, The Netherlands
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Summary

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Haemagglutination inhibition (HI) antibodies against the influenza viruses A/Hong Kong/8/68 (H3N2) and B/Nederland/77/66 were determined in 420 paired sera from mothers and newborns (umbilical cord sera), sampled in 1970–1.

A higher concentration of antibodies against influenza A virus was found more frequently in neonatal than in maternal sera. By contrast, low titres against influenza B virus were more frequently observed in neonatal than in maternal sera. Maternal age, duration of pregnancy, and birth-weight did not affect the results of the tests.

It is suggested that the titre of the newborn against an epidemic influenza virus can be predicted from that of the mother. Furthermore, the maternal titre may be an indication of the susceptibility of the newborn infant to influenza infections.

Type
Research Article
Information
Journal of Hygiene , Volume 80 , Issue 1 , February 1978 , pp. 13 - 19
Copyright
Copyright © Cambridge University Press 1978

References

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