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Histopathology of the stapes in osteogenesis imperfecta

Published online by Cambridge University Press:  29 June 2007

Ulrik Pedersen ,
Flemming Melsen ,
Ole Elbrønd  and
Peder Charles
Ulrik Pedersen*
Affiliation:
University Departments of Otorhinolaryngology
Flemming Melsen
Affiliation:
Aarhus Kommunehospital, and theUniversity Institute of Pathology, Aarhus Amtssygehus, Aarhus, Denmark.
Ole Elbrønd
Affiliation:
University Departments of Otorhinolaryngology
Peder Charles
Affiliation:
Nuclear Medicine
*
ENT Department, Aarhus kommunehospital, DK-8000, Aarhus C, Denmark.
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Summary

Conventional histological studies of stapes footplates from patients with osteogenesis imperfecta revealed, in nine out of 15 stapes examined, an otospongiotic-like lesion. Although the morphology of the stapedial lesion was comparable to the early otosclerotic focus, a greater structural disorganization and larger resorption spaces in osteogenesis imperfecta distinguished the two conditions. The histopathology of the stapes was related to the morphology of cortical and trabecular bone from the iliac crest. Various degrees of immature, osteogenic bony tissue were found in the iliac crest, showing no resemblance to the otospongiotic-like focus in the footplate. Even though the histologic appearance of the stapes footplates differed from the findings in peripheral bone, the present study indicates that the stapedial lesion in osteogenesis imperfecta is most likely a manifestation of the generalized bone and connective tissue disorder. The study further supports the view that osteogenesis imperfecta and otosclerosis are of different aetiology.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 99 , Issue 5 , May 1985 , pp. 451 - 458
Copyright
Copyright © JLO (1984) Limited 1985

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