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Metastatic bone marrow involvement from supraglottic squamous cell carcinoma

Published online by Cambridge University Press:  29 June 2007

G. C. Toner ,
R. L. Thomas  and
M. A. Schwarz
G. C. Toner*
Affiliation:
Fellow in Medical Oncology; From the Medical Oncology and ENT Units of the Alfred Hospital, Melbourne, Australia
R. L. Thomas
Affiliation:
Consultant Ear, Nose and Throat Surgeon; From the Medical Oncology and ENT Units of the Alfred Hospital, Melbourne, Australia
M. A. Schwarz
Affiliation:
Consultant Medical Oncologist. From the Medical Oncology and ENT Units of the Alfred Hospital, Melbourne, Australia
*
Dr Guy C. Toner, Fellow in Medical Oncology, Box 191, Memorial Sloan-Kettering Cancer Centre, 1275 York Avenue, New York NY 10021
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Abstract

A case of an aggressive supraglottic squamous cell carcinoma, which was managed with neo-adjuvant chemotherapy and radical surgery, is described. The post-operative course was of rapid deterioration and death due to progressive metastatic disease involving bone marrow and liver. This is the first reported case of bone marrow infiltration by squamous cell carcinoma of the head and neck diagnosed ante-mortem. The incidence and pattern of metastatic disease from head and neck tumours is reviewed, and the importance of initial staging in determining the risk of distant metastatic disease is emphasised.

Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 103 , Issue 2 , February 1989 , pp. 225 - 226
Copyright
Copyright © JLO (1984) Limited 1989

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References

Burke, E. M. (1937) Metastases in squamous cell carcinoma. American Journal of Cancer, 30: 493–503.CrossRefGoogle Scholar
Crile, G. (1906) Excision of cancer of the head and neck: with special reference to the plan of dissection based on 132 operations. Journal of the American Medical Association, 47: 1780–1785.CrossRefGoogle Scholar
Ervin, T. J., Weichselbaum, R., Miller, D., Meshad, M., Posner, M., Fabian, R. (1981) Treatment of advanced squamous cell carcinoma of the head and neck with cisplatin, bleomycin, and methotrexate (PBM). Cancer Treatment Reports, 65: 787–791.Google ScholarPubMed
Merino, O. R., Lindberg, R. D., Fletcher, G. H. (1977) An analysis of distant metastases from squamous cell carcinoma of the upper respiratory and digestive tracts. Cancer, 40: 145–151.3.0.CO;2-9>CrossRefGoogle ScholarPubMed
O'Brien, P. H., Carlson, R., Steubner, E. A., Staley, C. T. (1971) Distant metastases in epidermoid cell carcinoma of the head and neck. Cancer, 27: 304–307.3.0.CO;2-1>CrossRefGoogle ScholarPubMed
Peltier, L. F., Thomas, L. B., Crawford Barclay, T. H., Kremen, A. J. (1951) The incidence of distant metastases among patients dying with head and neck cancers. An analysis of 200 autopsies. Surgery, 30: 827–833.Google ScholarPubMed
Price, L. W. (1934) Metastasis in squamous carcinoma. American Journal of Cancer, 22: 1–16.Google Scholar
Probert, J. C., Thomson, R. W., Bagshaw, M. A. (1974) Patterns of spread of distant metastases in head and neck cancer. Cancer, 33: 127–133.3.0.CO;2-L>CrossRefGoogle ScholarPubMed
Vogl, S. E. and Kaplan, B. H. (1979) Chemotherapy of advanced head and neck cancer with methotrexate, bleomycin, and cisdiamminedichloroplatinum II in an effective outpatient schedule. Cancer, 44: 26–31.3.0.CO;2-W>CrossRefGoogle Scholar