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Recurrent laryngeal papillomatosis developing into laryngeal carcinoma with human papilloma virus (HPV) type 18: a case report

Published online by Cambridge University Press:  29 June 2007

Atsushi Sakakura ,
Yuzo Yamamoto ,
Tomohiko Takasaki ,
Kazuo Makimoto ,
Masahiro Nakamura  and
Hiroaki Takahashi
Atsushi Sakakura*
Affiliation:
Department of Otolaryngology, Osaka Medical College, 2–7 Daigakucho, Takatsuki, Osaka 569, Japan
Yuzo Yamamoto
Affiliation:
Department of Otolaryngology, Osaka Medical College, 2–7 Daigakucho, Takatsuki, Osaka 569, Japan
Tomohiko Takasaki
Affiliation:
Department of Bacteriology, Kinki University School of Medicine, 377–2 Ohno Higashi Osakasayama, 589, Japan
Kazuo Makimoto
Affiliation:
Department of Otolaryngology, Osaka Medical College, 2–7 Daigakucho, Takatsuki, Osaka 569, Japan
Masahiro Nakamura
Affiliation:
Department of Otolaryngology, Osaka Medical College, 2–7 Daigakucho, Takatsuki, Osaka 569, Japan
Hiroaki Takahashi
Affiliation:
Department of Otolaryngology, Osaka Medical College, 2–7 Daigakucho, Takatsuki, Osaka 569, Japan
*
Address for correspondence: Atsushi Sakakura, Department of Otolaryngology, Osaka Medical College, 2–7 Daigakucho, Takatsuki, Osaka 569, Japan. Fax: 0726-84-6539
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Abstract

We report a case of recurrent laryngeal papillomatosis which developed into laryngeal squamous cell carcinoma 11 years after the first diagnosis. Interestingly, we could identify HPV type 18 DNA in the carcinoma tissue using the polymerase chain reaction (PCR). Other known risk factors of irradiation, smoking, exposure to chemical agents, or a hereditary tendency to malignant tumours were not present in this case. Our finding suggests that HPV type 18 is another aetiological agent for laryngeal carcinoma.

Keywords

PapillomatosisHuman papilloma virusesLaryngeal neoplasms
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 110 , Issue 1 , January 1996 , pp. 75 - 77
Copyright
Copyright © JLO (1984) Limited 1996

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