Hostname: page-component-8448b6f56d-qsmjn Total loading time: 0 Render date: 2024-04-23T06:05:52.879Z Has data issue: false hasContentIssue false

Diagnosis and treatment of acute otitis media: review

Published online by Cambridge University Press:  19 July 2012

Edward C Toll
Affiliation:
University College London Ear Institute, UK
Desmond A Nunez*
Affiliation:
Academic Department of Otolaryngology/Head and Neck Surgery, ENT Unit, Southmead Hospital, Bristol, UK
*
Address for correspondence: Desmond A Nunez, MD FRCS(ORL) Associate Professor & Head University of British Columbia, Division of Otolaryngology – Head and Neck Surgery, Vancouver Hospital, Diamond Health Care Centre, 4th Floor, 2775 Laurel Street, Vancouver, BC, CanadaV5Z 1M9 E-mail: desmond.nunez@ubc.ca

Abstract

Background:

Acute otitis media is very common, but diagnostic criteria and treatment recommendations vary considerably.

Methods:

Medline, the Cochrane Database of Systematic Reviews and the Cochrane Central Register of Controlled Trials were searched using the key words ‘acute otitis media’ AND ‘diagnosis’ OR ‘diagnostic criteria’ OR ‘definition’, and by combining the terms ‘acute otitis media’ AND ‘guidelines’. PubMed was searched using the key words ‘mastoiditis’ and ‘prevalence’.

Results:

The 11 most recently published guidelines unanimously agreed that adequate analgesia should be prescribed in all cases. The majority recommended that routine antibiotic prescription should be avoided in mild to moderate cases and when there was diagnostic uncertainty in patients two years and older. Antibiotics were recommended in children two years and younger, most commonly a 5-day course of amoxicillin (or a macrolide in patients allergic to penicillin).

Conclusion:

Level 1A evidence shows that selected cases of acute otitis media benefit from antibiotic prescription.

Type
Review Article
Copyright
Copyright © JLO (1984) Limited 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1HESonline: Primary Diagnosis: 4 character. In: http://www.hesonline.nhs.uk/Ease/servlet/ContentServer?siteID=1937&categoryID=214 [04 October 2010]Google Scholar
2Hayden, GF. Acute suppurative otitis media in children. Diversity of clinical diagnostic criteria. Clin Pediatr (Phila) 1981;20:99104CrossRefGoogle ScholarPubMed
3American Academy of Pediatrics Subcommittee on Management of Acute Otitis Media. Diagnosis and management of acute otitis media. Pediatrics 2004;113:1451–65CrossRefGoogle Scholar
4Marcy, M, Takata, G, Shekelle, P, Chan, LS, Mason, W, Wachsman, L et al. Management of Acute Otitis Media. Evidence Report/Technology Assessment No. 15. Rockville, Maryland: Agency for Healthcare Research and Quality, 2001Google Scholar
5Brookhouser, PE. Use of tympanometry in office practice for diagnosis of otitis media. Pediatr Infect Dis J 1998;17:544–51, 580CrossRefGoogle ScholarPubMed
6Kimball, S. Acoustic reflectometry: spectral gradient analysis for improved detection of middle ear effusion in children. Pediatr Infect Dis J 1998;17:552–5, 580CrossRefGoogle ScholarPubMed
7Barnett, ED, Klein, JO, Hawkins, KA, Cabral, HJ, Kenna, M, Healy, G. Comparison of spectral gradient acoustic reflectometry and other diagnostic techniques for detection of middle ear effusion in children with middle ear disease. Pediatr Infect Dis J 1998;17:556–9, 580CrossRefGoogle ScholarPubMed
8Block, SL, Mandel, E, McLinn, S, Pichichero, ME, Bernstein, S, Kimball, S et al. Spectral gradient acoustic reflectometry for the detection of middle ear effusion by pediatricians and parents. Pediatr Infect Dis J 1998;17:560–4, 580CrossRefGoogle ScholarPubMed
9Block, SL, Pichichero, ME, McLinn, S, Aronovitz, G, Kimball, S. Spectral gradient acoustic reflectometry: detection of middle ear effusion in suppurative acute otitis media. Pediatr Infect Dis J 1999;18:741–4CrossRefGoogle ScholarPubMed
10Spiro, DM, King, WD, Arnold, DH, Johnston, C, Baldwin, S. A randomized clinical trial to assess the effects of tympanometry on the diagnosis and treatment of acute otitis media. Pediatrics 2004;114:177–81CrossRefGoogle ScholarPubMed
11Karma, PH, Penttila, MA, Sipila, MM, Kataja, MJ. Otoscopic diagnosis of middle ear effusion in acute and non-acute otitis media. I. The value of different otoscopic findings. Int J Pediatr Otorhinolaryngol 1989;17:3749CrossRefGoogle ScholarPubMed
12Karma, PH, Sipila, MM, Kataja, MJ, Penttila, MA. Pneumatic otoscopy and otitis media. II. Value of different tympanic membrane findings and their combinations. In: Lim, DJ, Bluestone, CD, Klein, JO, Nelson, JD, Ogra, PL, eds. Recent Advances in Otitis Media: Proceedings of the Fifth International Symposium. Burlington, Ontario, Canada: Decker Periodicals, 1993;41–5Google Scholar
13Pelton, SI. Otoscopy for the diagnosis of otitis media. Pediatr Infect Dis J 1998;17:540–3, 580CrossRefGoogle ScholarPubMed
14CKS Clinical Knowledge Summaries. In: http://www.cks.nhs.uk/otitis_media_acute [14 April 2010]Google Scholar
15Rothman, R, Owens, T, Simel, DL. Does this child have acute otitis media? JAMA 2003;290:1633–40CrossRefGoogle ScholarPubMed
16Guideline for the Diagnosis and Management of Acute Otitis Media. In http://www.topalbertadoctors.org/download/364/AOM_brochure.pdf [08 February 2011]Google Scholar
17Cinncinatti Children's Hospital Medical Center, Health Policy & Clinical Effectiveness Program. Evidence-based Clinical Practice Guideline for Medical Management of Acute Otitis Media in Children 2 Months to 13 Years of Age. In http://www.cincinnatichildrens.org/WorkArea/linkit.aspx?LinkIdentifier=id&ItemID=87856&libID=87544 [08 February 2011]Google Scholar
18Guidelines and Protocols Advisory committee Acute Otitis Media (AOM) Revised 2004. In http://www.bcguidelines.ca/pdf/otitaom.pdf [08 February 2011]Google Scholar
19French Health Products Safety Agency. Antibiotic Therapy in Clinical Practice in Upper Respiratory Tract Infections in Adults and Children [in French]. In http://www.infectiologie.com/site/medias/_documents/consensus/2005-infVRB-argu-afssaps.pdf [01 April 2010]Google Scholar
20Asher, E, Leibovitz, E, Press, J, Greenberg, D, Bilenko, N, Reuveni, H. Accuracy of acute otitis media diagnosis in community and hospital settings. Acta Paediatr 2005;94:423–8CrossRefGoogle ScholarPubMed
21Pichichero, ME, Poole, MD. Assessing diagnostic accuracy and tympanocentesis skills in the management of otitis media. Arch Pediatr Adolesc Med 2001;155:1137–42CrossRefGoogle ScholarPubMed
22Legros, JM, Hitoto, H, Garnier, F, Dagorne, C, Dubin, J, Fanello, S. Reliability of the diagnosis of acute otitis media by general practitioners [in French]. Arch Pediatr 2007;14:427–33CrossRefGoogle ScholarPubMed
23Hemlin, C, Hassler, E, Hultcrantz, M, Papatziamos, G, Krakau, I. Aspects of diagnosis of acute otitis media. Fam Pract 1998;15:133–7CrossRefGoogle ScholarPubMed
24Wormald, PJ, Browning, GG, Robinson, K. Is otoscopy reliable? A structured teaching method to improve otoscopic accuracy in trainees. Clin Otolaryngol Allied Sci 1995;20:63–7CrossRefGoogle ScholarPubMed
25Froom, J, Culpepper, L, Grob, P, Bartelds, A, Bowers, P, Bridges-Webb, C et al. Diagnosis and antibiotic treatment of acute otitis media: report from International Primary Care Network. BMJ 1990;300:582–6CrossRefGoogle ScholarPubMed
26National Institute of Health and Clinical Excellence. NICE Clinical Guideline No. 69: Respiratory Tract Infections – Antibiotic Prescribing. London: National Institute of Health and Clinical Excellence, 2008Google Scholar
27Glasziou, PP, Del Mar, CB, Sanders, SL, Hayem, M. Antibiotics for acute otitis media in children. Cochrane Database Syst Rev 2004;(1):CD000219Google ScholarPubMed
28Rovers, MM, Glasziou, P, Appelman, CL, Burke, P, McCormick, DP, Damoiseaux, RA et al. Antibiotics for acute otitis media: a meta-analysis with individual patient data. Lancet 2006;368:1429–35CrossRefGoogle ScholarPubMed
29Spiro, DM, Tay, KY, Arnold, DH, Dziura, JD, Baker, MD, Shapiro, ED. Wait-and-see prescription for the treatment of acute otitis media: a randomized controlled trial. JAMA 2006;296:1235–41CrossRefGoogle ScholarPubMed
30Little, P, Gould, C, Williamson, I, Moore, M, Warner, G, Dunleavey, J. Pragmatic randomised controlled trial of two prescribing strategies for childhood acute otitis media. BMJ 2001;322:336–42CrossRefGoogle ScholarPubMed
31McCormick, DP, Chonmaitree, T, Pittman, C, Saeed, K, Friedman, NR, Uchida, T et al. Nonsevere acute otitis media: a clinical trial comparing outcomes of watchful waiting versus immediate antibiotic treatment. Pediatrics 2005;115:1455–65CrossRefGoogle ScholarPubMed
32Appelman, CLM, van Balen, FAM, van de Lisdonk, EH, van Weert, HCPM, Eizenga, WH. NHG Clinical Practice Guidelines: M09 Acute Otitis Media. Amsterdam: Dutch College of General Practitioners, 2006Google Scholar
33Scottish Intercollegiate Guidelines Network 66 Diagnosis and management of childhood otitis media in primary care. A national clinical guideline. In http://www.sign.ac.uk/guidelines/fulltext/66/index.html [17 December 2010]Google Scholar
34Damoiseaux, RA, van Balen, FA, Hoes, AW, Verheij, TJ, de Melker, RA. Primary care based randomised, double blind trial of amoxicillin versus placebo for acute otitis media in children aged under 2 years. BMJ 2000;320:350–4CrossRefGoogle ScholarPubMed
35Rosenfeld, RM, Vertrees, JE, Carr, J, Cipolle, RJ, Uden, DL, Giebink, GS et al. Clinical efficacy of antimicrobial drugs for acute otitis media: meta-analysis of 5400 children from thirty-three randomized trials. J Pediatr 1994;124:355–67CrossRefGoogle ScholarPubMed
36Del Mar, C, Glasziou, P, Hayem, M. Are antibiotics indicated as initial treatment for children with acute otitis media? A meta-analysis. BMJ 1997;314:1526–9CrossRefGoogle ScholarPubMed
37Pshetizky, Y, Naimer, S, Shvartzman, P. Acute otitis media – a brief explanation to parents and antibiotic use. Fam Pract 2003;20:417–19CrossRefGoogle ScholarPubMed
38Siegel, RM, Kiely, M, Bien, JP, Joseph, EC, Davis, JB, Mendel, SG et al. Treatment of otitis media with observation and a safety-net antibiotic prescription. Pediatrics 2003;112:527–31CrossRefGoogle Scholar
39University of Michigan Health System. Guidelines for Clinical Care. Otitis Media. In http://cme.med.umich.edu/pdf/guideline/om.pdf [accessed 18 February 2011]Google Scholar
40Hoberman, A, Paradise, JL, Rockette, HE, Shaikh, N, Wald, ER, Kearney, DH et al. Treatment of acute otitis media in children under 2 years of age. N Engl J Med 2011;364:105–15CrossRefGoogle Scholar
41van Buchem, FL, Peeters, MF, van't Hof, MA. Acute otitis media: a new treatment strategy. Br Med J (Clin Res Ed) 1985;290:1033–7CrossRefGoogle ScholarPubMed
42Grossman, Z, Silverman, BG, Porter, B, Miron, D. Implementing the delayed antibiotic therapy approach significantly reduced antibiotics consumption in Israeli children with first documented acute otitis media. Pediatr Infect Dis J 2010;29:595–9CrossRefGoogle ScholarPubMed
43Otitis media (acute). Current Care guideline. Working group appointed by the Finnish Medical Society Duodecim, the Finnish Paediatric Society, the Finnish Otolaryngological Society and the Finnish Association for Central Practice. Helsinki: Finnish Medical Society Duodecim, 2010. In http://www.kaypahoito.fi [In Finnish, accessed 8 February 2011]Google Scholar
44Keith, T, Saxena, S, Murray, J, Sharland, M. Risk-benefit analysis of restricting antimicrobial prescribing in children: what do we really know? Curr Opin Infect Dis 2010;23:242–8CrossRefGoogle ScholarPubMed
45Sharland, M, Kendall, H, Yeates, D, Randall, A, Hughes, G, Glasziou, P et al. Antibiotic prescribing in general practice and hospital admissions for peritonsillar abscess, mastoiditis, and rheumatic fever in children: time trend analysis. BMJ 2005;331:328–9CrossRefGoogle ScholarPubMed
46Van Zuijlen, DA, Schilder, AG, Van Balen, FA, Hoes, AW. National differences in incidence of acute mastoiditis: relationship to prescribing patterns of antibiotics for acute otitis media? Pediatr Infect Dis J 2001;20:140–4CrossRefGoogle ScholarPubMed
47Molstad, S, Erntell, M, Hanberger, H, Melander, E, Norman, C, Skoog, G et al. Sustained reduction of antibiotic use and low bacterial resistance: 10-year follow-up of the Swedish Strama programme. Lancet Infect Dis 2008;8:125–32CrossRefGoogle ScholarPubMed
48Thompson, PL, Gilbert, RE, Long, PF, Saxena, S, Sharland, M, Wong, IC. Effect of antibiotics for otitis media on mastoiditis in children: a retrospective cohort study using the United Kingdom general practice research database. Pediatrics 2009;123:424–30CrossRefGoogle ScholarPubMed
49Petersen, I, Johnson, AM, Islam, A, Duckworth, G, Livermore, DM, Hayward, AC. Protective effect of antibiotics against serious complications of common respiratory tract infections: retrospective cohort study with the UK General Practice Research Database. BMJ 2007;335:982CrossRefGoogle ScholarPubMed
50Dagan, R, McCracken, GH Jr. Flaws in design and conduct of clinical trials in acute otitis media. Pediatr Infect Dis J 2002;21:894902CrossRefGoogle ScholarPubMed
51Joint Formulary Committee. British National Formulary 59. London: BMJ Publishing/RPS Publishing, 2010Google Scholar
52Kozyrskyj, AL, Hildes-Ripstein, GE, Longstaffe, SE, Wincott, JL, Sitar, DS, Klassen, TP et al. Short course antibiotics for acute otitis media. Cochrane Database Syst Rev 2000;(2):CD001095CrossRefGoogle ScholarPubMed
53Cohen, R, Levy, C, Boucherat, M, Langue, J, de la Rocque, F. A multicenter, randomized, double-blind trial of 5 versus 10 days of antibiotic therapy for acute otitis media in young children. J Pediatr 1998;133:634–9CrossRefGoogle ScholarPubMed
54Kozyrskyj, AL, Hildes-Ripstein, GE, Longstaffe, SE, Wincott, JL, Sitar, DS, Klassen, TP et al. Treatment of acute otitis media with a shortened course of antibiotics: a meta-analysis. JAMA 1998;279:1736–42CrossRefGoogle ScholarPubMed
55Kaleida, PH, Casselbrant, ML, Rockette, HE, Paradise, JL, Bluestone, CD, Blatter, MM et al. Amoxicillin or myringotomy or both for acute otitis media: results of a randomized clinical trial. Pediatrics 1991;87:466–74CrossRefGoogle ScholarPubMed
56Culpepper, L. Tympanocentesis: to tap or not to tap. Am Fam Physician 2000;61:1987–92Google ScholarPubMed
57Pichichero, ME. Acute otitis media: Part I. Improving diagnostic accuracy. Am Fam Physician 2000;61:2051–6Google ScholarPubMed
58Anekwe, L. Grommets Effective for Recurrent Otitis Media. In http://www.pulsetoday.co.uk/newsarticle-content [accessed 12 November 2010]Google Scholar
59McDonald, S, Langton Hewer, CD, Nunez, DA. Grommets (ventilation tubes) for recurrent acute otitis media in children. Cochrane Database Syst Rev 2008;(4)CD004741CrossRefGoogle ScholarPubMed
60Schilder, AG, Lok, W, Rovers, MM. International perspectives on management of acute otitis media: a qualitative review. Int J Pediatr Otorhinolaryngol 2004;68:2936CrossRefGoogle ScholarPubMed
61Pothier, DD, Toll, EC, Grant, DG, Giddings, CE. Trends in operative training opportunities for junior and senior trainees in otolaryngology. Clin Otolaryngol 2009;34:179–84CrossRefGoogle ScholarPubMed
62Grijalva, CG, Nuorti, JP, Griffin, MR. Antibiotic prescription rates for acute respiratory tract infections in US ambulatory settings. JAMA 2009;302:758–66CrossRefGoogle ScholarPubMed
63McCaig, LF, Besser, RE, Hughes, JM. Trends in antimicrobial prescribing rates for children and adolescents. JAMA 2002;287:3096–102CrossRefGoogle ScholarPubMed
64Gulliford, M, Latinovic, R, Charlton, J, Little, P, van Staa, T, Ashworth, M. Selective decrease in consultations and antibiotic prescribing for acute respiratory tract infections in UK primary care up to 2006. J Public Health (Oxf) 2009;31:512–20CrossRefGoogle ScholarPubMed
65Vernacchio, L, Vezina, RM, Mitchell, AA. Management of acute otitis media by primary care physicians: trends since the release of the 2004 American Academy of Pediatrics/American Academy of Family Physicians clinical practice guideline. Pediatrics 2007;120:281–7CrossRefGoogle Scholar
66Ganga-Zandzou, PS, Fermantel, A, Robic, C, Pouessel, G, Pierre, MH, Bourgois, B et al. Assessment of the management of acute otitis media in children by family practitioners in the North of France [in French]. Presse Med 2009;38:1730–7CrossRefGoogle ScholarPubMed