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The influence of genes mapping within the major histocompatibility complex on resistance to Trichuris muris infections in mice

Published online by Cambridge University Press:  06 April 2009

K. J. Else ,
D. Wakelin ,
D. L. Wassom  and
K. M. Hauda
K. J. Else
Affiliation:
MRC Experimental Parasitology Unit, Department of Zoology, Nottingham University, University Park, Nottingham NG7 2RD, UK
D. Wakelin
Affiliation:
MRC Experimental Parasitology Unit, Department of Zoology, Nottingham University, University Park, Nottingham NG7 2RD, UK
D. L. Wassom
Affiliation:
Department of Pathobiological Sciences, University of Wisconsin-Madison, School of Veterinary Medicine, 2015 Linden Drive West, Madison, Wisconsin 53706USA
K. M. Hauda
Affiliation:
Department of Pathobiological Sciences, University of Wisconsin-Madison, School of Veterinary Medicine, 2015 Linden Drive West, Madison, Wisconsin 53706USA
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Summary

Two panels of H-2 recombinant strains of mice were used in an attempt to map the H-2-linked genes which control resistance to infection with Trichuris muris. Response phenotypes could be related to the presence of ‘resistance’ (q, b) or ‘susceptibility’ (k, d) alleles at I-A. The influence of these genes was modulated by other alleles, particularly q or d alleles, at the D end of the H-2. Absence of I-E molecules correlated with resistance to infection in some but not all strains studied. Thus the (B10.BR × B10.G) Fl strain which expressed I-Ek gene products was resistant to infection. A study of the time-course of infection in strains of mice expressing q alleles throughout the H-2 on 4 different genetic backgrounds (NIH, SWR, DBA and B10) revealed that most strains were resistant to infection. However, the DBA/1 strain exhibited differential responsiveness, 4 out of 6 individuals harbouring mature adult parasites on day 35 post-infection.

Keywords

H-2 recombinantTrichuris murismajor histocompatibility complexresistancegenetic control
Type
Research Article
Information
Parasitology , Volume 101 , Issue 1 , August 1990 , pp. 61 - 67
Copyright
Copyright © Cambridge University Press 1990

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