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Depletion of CD4+ or CD8+ T-cells prevents Plasmodium berghei induced cerebral malaria in end-stage disease

Published online by Cambridge University Press:  01 January 1997

C. HERMSEN ,
T. VAN DE WIEL ,
E. MOMMERS ,
R. SAUERWEIN  and
W. ELING
C. HERMSEN
Affiliation:
University of Nijmegen, Department of Medical Microbiology, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
T. VAN DE WIEL
Affiliation:
University of Nijmegen, Department of Medical Microbiology, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
E. MOMMERS
Affiliation:
University of Nijmegen, Department of Medical Microbiology, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
R. SAUERWEIN
Affiliation:
University of Nijmegen, Department of Medical Microbiology, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
W. ELING
Affiliation:
University of Nijmegen, Department of Medical Microbiology, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
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Abstract

The role of T-cells in development of experimental cerebral malaria was analysed in C57B1/6J and C57B1/10 mice infected with Plasmodium berghei K173 or Plasmodium berghei ANKA by treatment with anti-CD4 or anti-CD8 mAbs. Mice were protected against cerebral malaria (CM) when anti-CD4 or anti-CD8 mAbs were injected before or during infection. Even in mice in end-stage disease, i.e. with a body temperature below 35·5 °C, treatment with anti-CD4 or anti-CD8 antibodies or the combination protected against CM, whereas chloroquine treatment was completely ineffective in inhibiting further development of the cerebral syndrome.

Keywords

Plasmodium bergheicerebral malariaprotectionCD4CD8blood–brain barrier
Type
Research Article
Information
Parasitology , Volume 114 , Issue 1 , January 1997 , pp. 7 - 12
Copyright
© 1997 Cambridge University Press

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