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Postural Sway and Effect of Levodopa in Early Parkinson's Disease

Published online by Cambridge University Press:  02 December 2014

Anne Beuter ,
Roberto Hernández ,
Robert Rigal ,
Julien Modolo  and
Pierre J. Blanchet
Anne Beuter
Affiliation:
The Institut de Cognitique, Université Victor Segalen Bordeaux 2, Bordeaux, France
Roberto Hernández
Affiliation:
Département de Kinanthropologie, Université du Québec à Montréal, Montréal
Robert Rigal
Affiliation:
Département de Kinanthropologie, Université du Québec à Montréal, Montréal
Julien Modolo
Affiliation:
The Institut de Cognitique, Université Victor Segalen Bordeaux 2, Bordeaux, France
Pierre J. Blanchet
Affiliation:
Département de Stomatologie, Faculté de Médecine Dentaire, Université de Montréal, et Unité des Troubles du Mouvement André-Barbeau, Centre Hospitalier de l'Université de Montréal, Quebec, Canada
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Abstract

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Objective:

To characterize postural stability control and levodopa responsiveness in early Parkinson's disease (PD).

Methods:

Postural sway was studied during quiet stance in ten patients within six years of PD onset, both before (OFF) and after (ON) regular oral levodopa dosing. Postural sway was recorded using a force platform during 30 sec with eyes open, and six dependent variables were examined.

Results:

Mild baseline subclinical changes in postural sway were recorded in our patients. Clear benefit was observed in five out of six characteristics (mean sway, transversal sway, sagittal sway, sway intensity, and sway area) in the ON condition.

Conclusion:

Postural control mechanisms are affected early in PD and modulated by dopamine.

Résumé:

RÉSUMÉ:<span class='italic'><span class='bold'>Objectif</span></span>:

Caractériser le contrôle postural et sa réponse à la L-DOPA dans la maladie de Parkinson (MP) à un stade peu évolué.

<span class='italic'><span class='bold'>Méthodologie</span></span>:

L'activité posturo-cinétique a été étudiée à l'orthostation au repos chez 10 patients souffrant de la MP depuis 1-6 ans, avant (état basal ou « OFF ») puis après (état « ON ») l'administration orale de leur dose régulière de L-DOPA. Cette activité a été enregistrée pendant 30 sec les yeux ouverts en utilisant une plateforme de force et 6 variables dépendantes ont été étudiées.

<span class='italic'><span class='bold'>Résultats</span></span>:

De légers changements infracliniques de l'activité posturo-cinétique ont été enregistrés chez les patients à l'état basal, et un bénéfice net a été observé sur 5 des 6 caractéristiques (oscillation moyenne, oscillation transversale, oscillation sagittale, intensité d'oscillation et aire d'oscillation) en condition « ON ».

<span class='italic'><span class='bold'>Conclusion</span></span>:

Les mécanismes de commande posturale sont affectés précocément dans la maladie de Parkinson et sont modulés par la dopamine.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 35 , Issue 1 , March 2008 , pp. 65 - 68
Copyright
Copyright © The Canadian Journal of Neurological 2008

References

1. Horak, FB, Frank, J, Nutt, JG. Effects of dopamine on postural control in parkinsonian subjects: scaling set and tone. J Neurophys. 1996; 75(6):2380–96.Google Scholar
2. Romero, DH, Stelmach, GE. Changes in postural control with aging and Parkinson’s disease. IEEE Eng Med Biol Mag. 2003; 22(2):27–31.CrossRefGoogle ScholarPubMed
3. Bessou, M, Severac Cauquil, A, Dupui, P, Montoya, R, Bessou, P. Specificity of the monocular crescents of the visual field in postural control. CR Acad Sci III. 1999; 322(9):749–57.Google Scholar
4. Kemoun, G, Watelain, E, Defebvre, L, Guieu, JD, Destee, A. Postural strategies and falls in elderly and in parkinsonism. Ann Readapt Med Phys. 2002; 4(9):485–92.CrossRefGoogle Scholar
5. Bazalgette, D, Zattara, M, Bouisset, S, Bathien, N, Rondot, P. Postural adjustments associated with rapid arm movements in Parkinson’s disease. In: Proceedings of VIIth International Symposium on Parkinson’s Disease. Adv Neurol. 1986; 45: 371–4.Google Scholar
6. Viitasalo, MK, Kampman, V, Sotaniemi, KA, Leppävuori, S, Myllylä, VV, Korpelainen, JT. Analysis of sway in Parkinson’s disease using a new inclinometry-based method. Mov Disord. 2002; 17(4):663–9.CrossRefGoogle ScholarPubMed
7. Rocchi, L, Chiari, L, Horak, FB. Effects of deep brain stimulation and levodopa on postural sway in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2002; 73: 267–74.Google Scholar
8. Hermanowicz, N. Management of Parkinson’s disease: strategies, pitfalls and future directions. Postgrad Med. 2001; 110(6):15–28.CrossRefGoogle ScholarPubMed
9. Despres, C, Lamoureux, D, Beuter, A. Standardization of a neuromotor test battery: The CATSYS System. Neurotoxicology. 2000; 21(5):725–36.Google ScholarPubMed
10. Bartolic, A, Pirtosek, Z, Rozman, J, Ribaric, S. Postural stability of Parkinson’s disease patients is improved by decreasing rigidity. Eur J Neurol. 2005; 12: 156–9.Google Scholar
11. Frank, JS, Horak, FB, Nutt, J. Centrally initiated postural adjustments in parkinsonian patients on and off levodopa. J Neurophys. 2000; 84: 2440–8.Google Scholar
12. Panzer-Decius, V, Nashner, LM, Beckley, DJ, Chase, TN. Quantification of dopaminomimetic effects on Parkinsonian symptoms using automatic and voluntary postural response. In: Przuntek, H, Kraus, PH, Klotz, P, Korczyn, AD, editors. Instrumental methods and scoring in extrapyramidal disorder. New York: Springer-Verlag; 1996. p. 150–60.Google Scholar
13. Horak, FB, Macpherson, JM. Postural orientation and equilibrium. In: Rowell, L, Shepherd, JT, editors. Regulations and integration of multiple systems. (Handbook of physiology, sect. 12, Exercise). New York:Oxford University Press; 1991. p. 255–92.Google Scholar
14. Horak, FB, Nutt, JG, Nashner, LM. Postural inflexibility in parkinsonian subjects. J Neurol Sci. 1992; 111: 46–58.Google Scholar
15. Horak, FB, Shupert, C. The role of the vestibular system in postural control. In: Herdman, S, editor. Vestibular Rehabilitation. New York: FA Davis; 1994. p. 22–46.Google Scholar
16. Nova, IC, Perracini, MR, Ferraz, HB. Levodopa effect upon functional balance of Parkinson’s disease patients. Parkinsonism Rel Disord. 2004; 10: 411–15.CrossRefGoogle ScholarPubMed
17. Bejjani, B-P, Gervais, D, Arnulf, I, Papadopoulos, S, Demeret, S, Bonnet, A-M, et al. Axial parkinsonian symptoms can be improved: the role of levodopa and bilateral subthalamic stimulation. J Neurol Neurosurg Psychiatry. 2000; 68: 595–600.CrossRefGoogle ScholarPubMed
18. Defebvre, LJP, Krystkowiak, P, Blatt, J-L, Duhamel, A, Bourriez, J-L, Perina, M, et al. Influence of pallidal stimulation and levodopa on gait and preparatory postural adjustments in Parkinson’s disease. Mov Disord. 2002; 17(1):76–83.Google Scholar
19. Maurer, C, Mergner, T, Peterka, RJ. Abnormal resonance behaviour of the postural control loop in Parkinson’s disease. Exp Brain Res. 2004; 157(3):369–76.Google Scholar
20. Dimitrova, D, Nutt, J, Horak, FB. Abnormal force patterns for multidirectional postural responses in patients with Parkinson’s disease. Exp Brain Res. 2004; 156: 183–95.Google Scholar