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A study of unusual Rayleigh matches in deutan deficiency

Published online by Cambridge University Press:  03 July 2008

J.L. BARBUR ,
M. RODRIGUEZ-CARMONA ,
J.A. HARLOW ,
K. MANCUSO ,
J. NEITZ  and
M. NEITZ
J.L. BARBUR*
Affiliation:
Applied Vision Research Centre, The Henry Wellcome Laboratories for Vision Sciences, City University, London, United Kingdom
M. RODRIGUEZ-CARMONA
Affiliation:
Applied Vision Research Centre, The Henry Wellcome Laboratories for Vision Sciences, City University, London, United Kingdom
J.A. HARLOW
Affiliation:
Applied Vision Research Centre, The Henry Wellcome Laboratories for Vision Sciences, City University, London, United Kingdom
K. MANCUSO
Affiliation:
Medical Collegeof Wisconsin, Department of Ophthalmology, Milwaukee, Wisconsin
J. NEITZ
Affiliation:
Medical Collegeof Wisconsin, Department of Ophthalmology, Milwaukee, Wisconsin
M. NEITZ
Affiliation:
Medical Collegeof Wisconsin, Department of Ophthalmology, Milwaukee, Wisconsin
*
Address correspondence and reprint requests to: John L. Barbur, Applied Vision Research Centre, The Henry Wellcome Laboratories for Vision Sciences, Northampton Square, City University, London EC1V 0HB, UK. E-mail: j.l.barbur@city.ac.uk
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Abstract

Rayleigh match data were modeled with the aim of explaining the locations of match midpoints and matching ranges, both in normal trichromats and in subjects with congenital color deficiency. Model parameters included the wavelength of peak sensitivity of cone photopigments, the effective photopigment optical density, and the noise amplitude in the red-green color channel. In order to avoid the suprathreshold, perceptual effects of extreme L:M cone ratios on color vision, selective post-receptoral amplification of cone signals is needed. The associated noise is also amplified and this causes corresponding changes in red-green threshold sensitivity. We propose that the noise amplitude and hence the size of the matching range in normal trichromats relates to the known inter-subject variation in the relative numbers of L and M cones. If this hypothesis can be shown to account for the extremes of the red-green matching range measured in normal trichromats, it is of interest to establish the extent to which it also predicts the unexpected, small matching ranges that are observed in some subjects with red-green color deficiency. A subset of subjects with deutan deficiency that exhibited less common Nagel matches were selected for genetic analysis of their cone pigment genes in order to confirm the type of deficiency, and to predict the corresponding peak wavelength separation (δλmax) of their two, long-wavelength cone pigments. The Rayleigh match model predicted accurately the midpoint and the range for the spectral differences specified by the genes. The prediction also required plausible selection of effective optical density of the cone pigments and noise. The noise needed varied, but the estimates were confined to lie within the limits established from the matching ranges measured in normal trichromats. The model predicts correctly the small matching ranges measured in some deuteranomalous subjects, principally accounted for by a low estimate of noise level in the red-green channel. The model also predicts the “normal” matches made by some subjects that rely on two hybrid genes and therefore exhibit red-green thresholds outside the normal range, typical of mild deuteranomaly.

Keywords

Color deficiencyRayleigh matchNagel anomaloscopeUnique yellowCone pigment genesL:M cone ratioCAD test
Type
Research Article
Information
Visual Neuroscience , Volume 25 , Issue 3 , May 2008 , pp. 507 - 516
Copyright
Copyright © Cambridge University Press 2008

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