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Isolated left ventricular non-compaction: the case for abnormal myocardial development

Published online by Cambridge University Press:  26 February 2007

Ross A. Breckenridge ,
Robert H. Anderson  and
Perry M. Elliott
Ross A. Breckenridge
Affiliation:
Department of Clinical Pharmacology, BHF Laboratories, University College, London
Robert H. Anderson
Affiliation:
Cardiac Unit, Institute of Child Heath, University College, London
Perry M. Elliott
Affiliation:
The Heart Hospital, University College, London
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Abstract

Isolated ventricular non-compaction is an increasingly commonly diagnosed myocardial disorder characterised by excessive and prominent trabeculation of the morphologically left, and occasionally the right, ventricle. This is associated with high rates of thromboembolism, cardiac failure, and cardiac arrhythmia. Recent improvements in understanding the embryonic processes underlying ventricular formation have led to the hypothesis that ventricular non-compaction is due to a failure of normal ventriculogenesis, leading to abnormal myocardium which may present clinically many years later. Experimental work in animal models provides several candidate transcription factors and signalling molecules that could, in theory, cause ventricular non-compaction if disrupted.

Keywords

hypertrabeculationmolecular biologytranscription factors
Type
Review Article
Information
Cardiology in the Young , Volume 17 , Issue 2 , April 2007 , pp. 124 - 129
Copyright
© 2007 Cambridge University Press

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