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Subclinical arterial stiffness in young children after Kawasaki disease

Published online by Cambridge University Press:  07 February 2013

Masato Oguri ,
Tsuneyuki Nakamura ,
Keita Tamanuki ,
Chisato Akita ,
Chika Kitaoka ,
Yutaka Saikawa  and
Masato Takahashi
Masato Oguri
Affiliation:
Department of Pediatrics, Kanazawa Medical University, Ishikawa, Japan
Tsuneyuki Nakamura*
Affiliation:
Department of Pediatrics, Kanazawa Medical University, Ishikawa, Japan Department of Pediatrics, Division of Cardiology, Children's Hospital Los Angeles, Los Angeles, United States of America
Keita Tamanuki
Affiliation:
Department of Pediatrics, Kanazawa Medical University, Ishikawa, Japan
Chisato Akita
Affiliation:
Department of Pediatrics, Kanazawa Medical University, Ishikawa, Japan
Chika Kitaoka
Affiliation:
Department of Pediatrics, Kanazawa Medical University, Ishikawa, Japan
Yutaka Saikawa
Affiliation:
Department of Pediatrics, Kanazawa Medical University, Ishikawa, Japan
Masato Takahashi
Affiliation:
Department of Pediatrics, Division of Cardiology, Children's Hospital Los Angeles, Los Angeles, United States of America
*
Correspondence to: Dr T. Nakamura, MD, PhD, Department of Pediatrics, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku, Ishikawa 920-0293, Japan. Tel: +81-76-286-3511; Fax: +81-76-286-8918; E-mail: p-tune@kanazawa-med.ac.jp
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Abstract

Background

Recent studies have revealed that atherosclerosis progresses faster than expected in young adults with a history of Kawasaki disease. However, it is unclear as to when these arterial changes become measurable. In this study, we evaluated subclinical arterial stiffness in young children with a history of Kawasaki disease using two-dimensional ultrasound speckle tracking.

Methods

A total of 75 children with a history of Kawasaki disease (mean age, 8.2 ± 2.8 years) and 50 healthy controls (mean age 8.3 ± 3.5 years) were included. The two regions of interest for speckle tracking were manually positioned at the anterior and posterior carotid arterial wall using a Philips iE33 (Philips Medical Systems, Bothell, WA, USA). The peak systolic strain, time to peak systolic strain, early systolic strain rate, and late systolic strain rate were continuously monitored between the two regions of interest. Furthermore, the intimal-medial thickness, stiffness β, and pressure-elastic modulus, as conventional measures of arterial stiffness, were concurrently obtained.

Results

The peak systolic strain and late systolic strain rate differed significantly between the patients with Kawasaki disease and controls (6.69% versus 8.60%, p < 0.01, and −0.28/second versus −0.51/second, p < 0.0001, respectively). There was no difference in the time to peak systolic strain, early systolic strain rate, and conventional measures.

Conclusions

The arteries of patients with Kawasaki disease appear to develop mild sclerotic changes shortly after the onset of the disease.

Keywords

Speckle trackingarteriosclerosiscarotid arterytwo-point strain
Type
Original Articles
Information
Cardiology in the Young , Volume 24 , Issue 1 , February 2014 , pp. 87 - 94
Copyright
Copyright © Cambridge University Press 2013 

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