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On Categorizing Gestational, Birth, and Neonatal Complications Following Late Pregnancy Exposure to Antidepressants: The Prenatal Antidepressant Exposure Syndrome

Published online by Cambridge University Press:  07 November 2014

Salvatore Gentile
Salvatore Gentile*
Affiliation:
ASL SalernoItaly
*
Dr. Salvatore Gentile, Department of Mental Health ASL Salerno, Mental Health Center 63 Cava de' Tirreni - Amalfi Coast, Piazza Galdi, 84013 Cava de' Tirreni (Salerno), Italy; Tel: 39-089-4455439, Fax, 39-0894455440; e-mail:, salvatore_gentile@alice.it.
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Abstract

Introduction: Late in utero exposure to antidepressants has been suspected of adversely impacting pregnancy outcome and compromising neonatal adaptation. Hence, the necessity exists to analyze published information on antidepressant use during late pregnancy to individuate potential recurrent patterns of iatrogenic complications.

Methods: Computerized searches on MEDLINE, PsyclNFO, ENBASE, and Cochrane Library through February 10, 2010 were performed for selecting literature information and investigating the safety of antidepressants when used during late pregnancy.

Results: Antidepressant treatment during late pregnancy may increase the rates of poor pregnancy outcome and neonatal withdrawal/ toxic reactions.

Conclusions: Because both gestational complications and neonatal adverse events acknowledge the same etiology, the author suggests including such iatrogenic events under the definition of prenatal antidepressant exposure syndrome, in order to increase clinicians' awareness about the spectrum of risks which may concern the mother-infant pair when antidepressant treatment is deemed indispensable during late pregnancy.

Type
Review Article
Information
CNS Spectrums , Volume 15 , Issue 3 , March 2010 , pp. 167 - 185
Copyright
Copyright © Cambridge University Press 2010

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