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Paternal contributions to large-for-gestational-age term babies: findings from a multicenter prospective cohort study

Published online by Cambridge University Press:  28 February 2019

J. G. B. Derraik Open the ORCID record for J. G. B. Derraik [Opens in a new window] ,
D. Pasupathy ,
L. M. E. McCowan ,
L. Poston ,
R. S. Taylor ,
N. A. B. Simpson ,
G. A. Dekker ,
J. Myers ,
M. C. Vieira  and
W. S. Cutfield
...Show all authors
J. G. B. Derraik
Affiliation:
Liggins Institute, University of Auckland, Auckland, New Zealand A Better Start – National Science Challenge, University of Auckland, Auckland, New Zealand Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden
D. Pasupathy
Affiliation:
Department of Women and Children’s Health, School of Life Course Sciences, King’s College, London, UK
L. M. E. McCowan
Affiliation:
Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand National Women’s Hospital, Auckland District Health Board, Auckland, New Zealand
L. Poston
Affiliation:
Department of Women and Children’s Health, School of Life Course Sciences, King’s College, London, UK
R. S. Taylor
Affiliation:
Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand
N. A. B. Simpson
Affiliation:
Section of Obstetrics and Gynaecology, Leeds Institute of Biomedical & Clinical Sciences, University of Leeds, Leeds, UK
G. A. Dekker
Affiliation:
Discipline of Obstetrics and Gynaecology, Adelaide Medical School, Robinson Research Institute, University of Adelaide, Adelaide, Australia
J. Myers
Affiliation:
Maternal and Fetal Heath Research Centre, University of Manchester, Manchester, UK
M. C. Vieira
Affiliation:
Department of Women and Children’s Health, School of Life Course Sciences, King’s College, London, UK
W. S. Cutfield
Affiliation:
Liggins Institute, University of Auckland, Auckland, New Zealand A Better Start – National Science Challenge, University of Auckland, Auckland, New Zealand
F. Ahlsson*
Affiliation:
Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden
*
Address for correspondence: Assoc. Prof. Fredrik Ahlsson, Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden. E-mail: fredrik.ahlsson@kbh.uu.se
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Abstract

We assessed whether paternal demographic, anthropometric and clinical factors influence the risk of an infant being born large-for-gestational-age (LGA). We examined the data on 3659 fathers of term offspring (including 662 LGA infants) born to primiparous women from Screening for Pregnancy Endpoints (SCOPE). LGA was defined as birth weight >90th centile as per INTERGROWTH 21st standards, with reference group being infants ⩽90th centile. Associations between paternal factors and likelihood of an LGA infant were examined using univariable and multivariable models. Men who fathered LGA babies were 180 g heavier at birth (P<0.001) and were more likely to have been born macrosomic (P<0.001) than those whose infants were not LGA. Fathers of LGA infants were 2.1 cm taller (P<0.001), 2.8 kg heavier (P<0.001) and had similar body mass index (BMI). In multivariable models, increasing paternal birth weight and height were independently associated with greater odds of having an LGA infant, irrespective of maternal factors. One unit increase in paternal BMI was associated with 2.9% greater odds of having an LGA boy but not girl; however, this association disappeared after adjustment for maternal BMI. There were no associations between paternal demographic factors or clinical history and infant LGA. In conclusion, fathers who were heavier at birth and were taller were more likely to have an LGA infant, but maternal BMI had a dominant influence on LGA.

Keywords

birth weightBMI, body mass indexfatherLGAmother
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 10 , Issue 5 , October 2019 , pp. 529 - 535
Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2019 

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