Hostname: page-component-7c8c6479df-hgkh8 Total loading time: 0 Render date: 2024-03-29T14:12:05.886Z Has data issue: false hasContentIssue false

Susceptibility of Nosocomial Staphylococcus aureus to Chlorhexidine After Implementation of a Hospital-wide Antiseptic Bathing Regimen

Published online by Cambridge University Press:  05 May 2017

Cole T. Marolf
Affiliation:
Department of Internal Medicine/Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, Nebraska
Roxanne Alter
Affiliation:
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska
Elizabeth Lyden
Affiliation:
Department of Epidemiology, University of Nebraska Medical Center, Omaha, Nebraska.
Paul D. Fey
Affiliation:
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska
Mark E. Rupp*
Affiliation:
Department of Internal Medicine/Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, Nebraska
*
Address correspondence to Mark E. Rupp, MD, 984031 Nebraska Medical Center, Omaha, NE 68198-4031 (merupp@unmc.edu).

Abstract

Hospital use of chlorhexidine (CHX) containing antiseptics to decrease nosocomial infections may promote CHX resistance among pathogenic organisms. Nosocomial bloodstream-infecting Staphylococcus aureus isolates from before and after adoption of hospital-wide CHX bathing were tested for CHX susceptibility, and no decreased susceptibility or resistance-promoting genes were discovered.

Infect Control Hosp Epidemiol 2017;38:873–875

Type
Concise Communications
Copyright
© 2017 by The Society for Healthcare Epidemiology of America. All rights reserved 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

PREVIOUS PRESENTATION. This study was presented in abstract form at the 5th Annual IDWeek, New Orleans, Louisiana, on October 27, 2016 (Poster #290).

References

REFERENCES

1. Milstone, AM, Passaretti, CL, Perl, TM. Chlorhexidine: expanding the armamentarium for infection control and prevention. Clin Infect Dis 2008;46:274281.Google ScholarPubMed
2. Kampf, G. Acquired resistance to chlorhexidine—is it time to establish an ‘antiseptic stewardship’ initiative? J Hosp Infect 2016;94:213227.CrossRefGoogle Scholar
3. Rupp, ME, Cavalieri, RJ, Lyden, E, et al. Effect of hospital-wide chlorhexidine patient bathing on healthcare-associated infections. Infect Control Hosp Epidemiol 2012;33:10941100.CrossRefGoogle ScholarPubMed
4. Paulsen, IT, Brown, MH, Littlejohn, TG, Mitchell, BA, Skurray, RA. Multidrug resistance proteins QacA and QacB from Staphylococcus aureus: membrane topology and identification of residues involved in substrate specificity. Proc Natl Acad Sci U S A 1996;93:36303635.CrossRefGoogle ScholarPubMed
5. McNeil, JC, Kok, EY, Vallejo, JG, et al. Clinical and molecular features of decreased chlorhexidine susceptibility among nosocomial Staphylococcus aureus isolates at Texas Children’s Hospital. Antimicrob Agents Chemother 2015;60:11211128.CrossRefGoogle ScholarPubMed
6. Lee, AS, Macedo-Vinas, M, Francois, P, et al. Impact of combined low-level mupirocin and genotypic chlorhexidine resistance on persistent methicillin-resistant Staphylococcus aureus carriage after decolonization therapy: a case-control study. Clin Infect Dis 2011;52:14221430.CrossRefGoogle ScholarPubMed
7. McGann, P, Kwak, YI, Summers, A, Cummings, JF, Waterman, PE, Lesho, EP. Detection of qacA/B in clinical isolates of methicillin-resistant Staphylococcus aureus from a regional healthcare network in the eastern United States. Infect Control Hosp Epidemiol 2011;32:11161119.CrossRefGoogle ScholarPubMed
8. McDanel, JS, Murphy, CR, Diekema, DJ, et al. Chlorhexidine and mupirocin susceptibilities of methicillin-resistant Staphylococcus aureus from colonized nursing home residents. Antimicrob Agents Chemother 2013;57:552558.CrossRefGoogle ScholarPubMed
9. Warren, DK, Prager, M, Munigala, S, et al. Prevalence of qacA/B Genes and mupirocin resistance among methicillin-resistant Staphylococcus aureus (MRSA) isolates in the setting of chlorhexidine bathing without mupirocin. Infect Control Hosp Epidemiol 2016;37:590597.CrossRefGoogle ScholarPubMed
10. Suwantarat, N, Carroll, KC, Tekle, T, et al. High prevalence of reduced chlorhexidine susceptibility in organisms causing central line-associated bloodstream infections. Infect Control Hosp Epidemiol 2014;35:11831186.CrossRefGoogle ScholarPubMed