Skip to main content
SpringerLink
Log in

The Prognostic Significance of Vascular Endothelial Growth Factor (VEGF C-1) Immunoexpression in Oligodendroglioma. An Analysis of 91 Cases

  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

Oligodendrogliomas continue to generate considerable difficulties in identifying prognostic factors, including single histopathological patterns. Among the latter, vascular productive changes have been intensively examined but the obtained results appear to be controversial. Numerous studies have revealed an indisputable importance of vascular endothelial growth factor (VEGF) immunoreactivity for malignant progression of astrocytomas but the data regarding oligodendrogliomas are heterogeneous. Ninety-one patients with oligodendroglioma were examined retrospectively for VECF immunoexpression. The results demonstrated significant preponderance of intracellular VEGF expression for WHO grade III tumors. Nevertheless, VEGF staining patterns correlated with both progression-free and overall survival only in univariate, but not in multivarite analysis. Only WHO tumor grade was found to be an independent prognostic factor for oligodendroglioma outcome. Therefore, it seems unlikely that VEGF immunohistochemistry will be of value in assessing individual oligodendroglioma prognosis, especially for determining of both progression-free and overall survival from histologically low-grade tumors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Bigner DD, McLendon RE, Bruner JM (eds): Russel and Rubinstein' Pathology of Tumors of the Nervous System. 6th edn. Arnold, London, 1998

    Google Scholar 

  2. Kleihues P, Burger PC, Scheithauer BW: Histological Typing of Tumors of the Central Nervous System: World Health Organization International Classification of Tumours. Springer, Berlin, 1993

    Google Scholar 

  3. Burger PC, Rawlings CE, Cox EB, McLendon RE, Schold Jr SC, Bullard DE: Clinicopathologic correlations in the oligodendroglioma. Cancer 59: 1345-1352, 1987

    Google Scholar 

  4. Celli P, Nofrone I, Palme L, Cantore G, Fortuna A: Cerebral oligodendroglioma: prognostic factors and life history. Neurosurgery 35: 1018-1035, 1994

    Google Scholar 

  5. Daumas-Duport C, Varlet P, Tucker ML, Beuvon F, Cervera P, Chodkiewicz JP: Oligodendrogliomas. Part I: Patterns of growth, histological diagnosis, clinical and imaging correlations: a study of 153 cases. J Neurooncol 34: 37-59, 1997

    Google Scholar 

  6. Daumas-Duport C, Tucker ML, Cervera P, Beuvon F, Varlet P, Udo N, Koziak M, Chodkiewicz JP: Oligodendrogliomas. Part II: A new grading system based on morphological and imaging criteria. J Neurooncol 34: 61-78, 1997

    Google Scholar 

  7. Dehghani F, Schachenmayr W, Laun A, Korf HW: Prognostic implication of histopathological, immunohistochemical and clinical features of oligodendrogliomas: a study of 89 cases. Acta Neuropathol (Berl) 95: 493-504, 1998

    Google Scholar 

  8. Fortin D, Cairncross GJ, Hammond RR: Oligodendroglioma: an appraisal of recent data pertaining to diagnosis and treatment. Neurosurgery 45: 1279-1291, 1999

    Google Scholar 

  9. Kros JM, Troost D, van Eden CC, Van der Werf AJM, Uylings HBM: Oligodendroglioma: a comparison of two grading systems. Cancer 61: 2251-2259, 1988

    Google Scholar 

  10. Kros JM, Pieterman H, van Eden CG, Avezaat CJJ: Oligodendroglioma: the Rotterdam-Dijkzigt experience. Neurosurgery 34: 959-966, 1994

    Google Scholar 

  11. Ludwig CL, Smith MT, Godfrey AD, Armbrustmacher VW: A clinicopathological study of 323 patients with oligodendrogliomas. Ann Neurol 19: 15-21, 1986

    Google Scholar 

  12. Mork SJ, Halvorsen TB, Lindegaard K-F, Eide GE: Oligodendroglioma. Histologic evaluation and prognosis. J Neuropathol Exp Neurol 45: 65-78, 1986

    Google Scholar 

  13. Schiffer D, Dutto A, Cavalla P, Bosone I, Chio A, Villani R, Bellotti C: Prognostic factors in oligodendrogliomas. Can J Neurol Sci 24: 313-319, 1997

    Google Scholar 

  14. Schiffer D, Bossone I, Dutto A, De Vito N, Chio A: The prognostic role of vessel productive changes and vessel density in oligodendroglioma. J Neuro-Oncol 44: 99-107, 1999

    Google Scholar 

  15. Shaw EG, Scheithauer BW, O'Fallon JR, Tazelaar HD, Davis DH: Oligodendrogliomas: the Mayo Clinic experience. J Neurosurg 76: 428-434, 1992

    Google Scholar 

  16. Smith MT, Ludwig CL, Godfrey AD, Armbrustmacher VW: Grading of oligodendrogliomas. Cancer 52: 2107-2114, 1983

    Google Scholar 

  17. Saito A, Nakazato Y: Evaluation of malignant features in oligodendroglial tumors. Clin Neuropathol 18: 61-73, 1999

    Google Scholar 

  18. Broholm H, Bols B, Heegard S, Broendstrup O: Immunohistochemical investigation of p53 and EGFR expression of oligodendrogliomas. Clin Neuropathol 18: 176-180, 1999

    Google Scholar 

  19. Cavalla P, Piva R, Bortolotto S, Grosso R, Cancelli I, Chio A, Schiffer D: p27/kip1 expression in oligodendrogliomas and its possible prognostic role. Acta Neuropathol (Berl) 98: 629-634, 1999

    Google Scholar 

  20. Coons SW, Johnson PC, Pearl DC: The prognostic significance of Ki-67 labeling indices for oligodendrogliomas. Neurosurgery 41: 878-884, 1997

    Google Scholar 

  21. Hagel C, Krog B, Laas R, Stavrou DK: Prognostic relevance of TP53 mutation, p53 protein, Ki-67 index and conventional histological grading in oligodendrogliomas. J Exp Clin Cancer Res 18: 305-309, 1999

    Google Scholar 

  22. Hagel C, Stavrou DK: CD44 expression in primary and recurrent oligodendrogliomas and in adjacent gliotic brain tissue. Neuropathol Appl Neurobiol 25: 311-318, 1999

    Google Scholar 

  23. Heegard S, Sommer HM, Broholm H, Broendstrup O: Proliferating cell nuclear antigen and Ki-67 immunohistochemistry of oligodendrogliomas with special reference to prognosis. Cancer 76: 1809-1813, 1995

    Google Scholar 

  24. Heesters MAAM, Koudstaal J, Go KG, Molenaar WM: Analysis of proliferation and apoptosis in brain gliomas: prognostic and clinical value. J Neuro-Oncol 44: 255-266, 1999

    Google Scholar 

  25. Kros JM, Godschalk JCJ, Krishnadath KK, van Eden CG: Expression of p53 in oligodendrogliomas. J Pathol 171: 285-290, 1993

    Google Scholar 

  26. Kros JM, Hop WCJ, Godschalk JCJ, Krishnadath KK: Prognostic value of the proliferation-related antigen Ki-67 in oligodendrogliomas. Cancer 78: 1107-1113, 1996

    Google Scholar 

  27. Miettinen H, Kononen J, Sallinen P, Alho H, Helen P, Helin H, Kalimo H, Paljarvi L, Isola J, Haapasalo H: CDKN2/p16 predicts survival in oligodendrogliomas: comparison with astrocytomas. J Neuro-Oncol 41: 205-211, 1999

    Google Scholar 

  28. Pavelic J, Hlavka V, Poljak M, Gale N, Pavelic K: p53 immunoreactivity in oligodendrogliomas. J Neuro-Oncol 22: 1-6, 1994

    Google Scholar 

  29. Reis-Filcho JS, Faoro LN, Carrilho C, Bleggi-Torres LF, Schmitt FC: Evaluation of cell proliferation, epidermal growth factor receptor and bcl-2 immunoexpression as prognostic factors for patients with World Health Organization grade 2 oligodendrogliomas. Cancer 88: 862-869, 2000

    Google Scholar 

  30. Wharton SB, Hamilton FA, Chan WK, Chan KK, Anderson JR: Proliferation and cell death in oligodendrogliomas. Neuropathol Appl Neurobiol 24: 21-28, 1998

    Google Scholar 

  31. Abdulrauf SI, Edvardsen K, Ho KL, Yang XY, Rock JP, Rosenblum ML: Vascular endothelial growth factor expression and vascular density as prognostic markers of survival in patients with low-grade gliomas. J Neurosurg 88: 513-520, 1998

    Google Scholar 

  32. Chan ASY, Leung SY, Wong MP, Yuen TS, Cheung N, Fan YW, Chung LP: Expression of vascular endothelial growth factor and its receptors in anaplastic progression of astrocytoma, oligodendroglioma and ependymoma. Am J Surg Pathol 22: 816-826, 1998

    Google Scholar 

  33. Oehring RD, Miletic M, Valter MM, Pietsch T, Neurmaun J, Fimmers R, Schlegel U: Vascular endothelial growth factor (VEGF) in astrocytic gliomas-a prognostic factor? J Neuro-Oncol 45: 117-125, 1999

    Google Scholar 

  34. Pietsch T, Valter MM, Wolf HK, von Deimling A, Huang HJ, Cavenee WK, Wiestler OD: Expression and distribution of vascular endothelial growth factor protein in human brain tumors. Acta Neuropathol (Berl) 93: 109-117, 1997

    Google Scholar 

  35. Plate KH, Breier G, Weich HA, Mennel HD, Risau W: Vascular endothelial growth factor and glioma angiogenesis: coordinate function of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms. Int J Cancer 59: 520-529, 1994

    Google Scholar 

  36. Plate KH, Risau W: Angiogenesis in malignant gliomas. Glia 15: 339-347, 1995

    Google Scholar 

  37. Christov C, Adle-Biassette H, Le Guerinel C, Natchev S, Gherardi RK: Immunohistochemical detection of vascular endothelial growth factor (VEGF) in the vasculature of oligodendrogliomas. Neuropathol Appl Neurobiol 24: 29-35, 1998

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neuropathology, Neurosurgical NN Burdenko Institute, Moscow, Russia

    Andrey Korshunov

  2. Department of Neurooncological Surgery, Neurosurgical NN Burdenko Institute, Moscow, Russia

    Andrey Golanov

Authors
  1. Andrey Korshunov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andrey Golanov
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Korshunov, A., Golanov, A. The Prognostic Significance of Vascular Endothelial Growth Factor (VEGF C-1) Immunoexpression in Oligodendroglioma. An Analysis of 91 Cases. J Neurooncol 48, 13–19 (2000). https://doi.org/10.1023/A:1006475312401

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1006475312401

Search

Navigation