Abstract
Successful microbial pathogens must be adept in obtaining growth-essential iron from healthy hosts. Some potential pathogens, however, are sufficiently impaired in iron acquisition ability so as to be dangerous mainly in hosts with such iron loading conditions as alcoholism, asplenia, hemochromatosis, β-thalassemia major, or tobacco smoking. The association of six impaired pathogens (Capnocytophaga canimorsis, Yersinia enterocolitica and Y. pseudotuberculosis, Vibrio vulnificus, Tropheryma whippelii, and Legionella pneumophila) with iron loaded humans is described.
References
Abbott M, Galloway A, Cunningham JL. 1986 Haemochromatosis presenting with a double yersinia infection. J Infec 13, 143–145.
Adamkiewicz TV, Berkovitch M, Krishnan C, Polsinelli C, Kermack D, Olivieri NF. 1998 Infection due to Yersinia enterocolitica in a series of patients with _-thalassemia: incidence and presdisposing factors. Clin Infec Dis 27, 1362–1366.
Adams PC, Gregor J. 1990 Hemochromatosis and yersiniosis. Can J Gastroenterol 4, 160–162.
Al-Khafaji B, Kralovic S, Smith RD. 1997 Increased hepatic iron in the acquiredimmunodeficiency syndrome: an autopsy study. Mod Pathol 10, 474–480.
Barnewall RE, Ohashsi N, Rikihisa Y. 1999 Ehrlichia chafeensis and E. sennetsu, but not the human granulocytic ehrlichiosis agent, colocalize with transferrin receptor mRNA by activating iron-responsive protein 1. Infec Immun 67, 2258–2265.
Blanche P, Bloch E, Sicard D. 1998 Capnocytophaga canimorsus in the oral flora of dogs and cats. J Infec 36, 134.
Boelaert JR, Weinberg GA, Weinberg ED. 1996 Altered iron metabolism in HIV infection:mechanisms, possible consequences, and proposals for management. Infec Agts Dis 5, 36–46.
Bothwelll/TH, MacPhail AP. 1998 Hereditary hemochromatosis: etiologic, pathologic, and clinical aspects. Sem Hematol 35, 55–71.
Bradley SJ, Gosriwitana I, Srichairatanakool S, Hider RC, Porter JB. 1997 Non-transferrin bound iron induced by myeloblative chemotherapy. Br J Haematol 99, 337–343.
Brenner DJ, Hollis DG, Fanning GR, Weaver RE. 1989 Capnocytophaga canimorsus sp. nov.(formerly CDC Group DF-2), a cause of septicemia following dog bite, and C. cynodegmi sp. nov., a cause of localized wound infection following dog bite. J Clin Microbiol 27, 231–235.
Bullen JJ, Spalding PB, Ward cg, Gutteridge JMC. 1991 Hemochromatosis, iron, and septicemia caused by Vibrio vulnificus. Arch Int Med 151, 1606–1609.
Byrd TF, Horwitz MA. 1991 Chloroquine inhibits the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. J Clin Inves 88, 351–357.
Capron J-P, Capron-Chivrac D, Tossou H, Delamarre J, Eb F. 1984 Spontaneous Yersinia enterocolitica peritonitis in idiopathic hemochromatosis. Gastroenterology 87, 1372–1375.
Chapman RW, Morgan MY, Bell R, Sherlock S. 1983 Hepatic iron uptake in alcoholic liverdisease. Gastroenterology 84, 143–147.
Dobbins WO III. 1995 Whipple's Disease. In: Mandell GL, Bennett JE, Dolin R, eds. Principles and practice of infectious diseases, 4th edit. New York: Churchill Livingstone; 1030–1032.
Duane P, Raja KB, Simpson RJ, Peters TJ. 1992 Intestinal iron absorption in chronic alcoholics. Alcohol Alcoholism 27, 539–544.
England AC III, Fraser DW. 1981 Sporadic and nosocomial legionellosis in the United States.Am J Med 78, 707–711.
Erlandson ME, Walden B, Stern G, Hilgartner MW, Wehman J, Smith CH. 1962 Studies on congenital hemolytic syndromes. IV. Gastrointestinal absorption of iron. Blood 19, 359–369.
Gubler GH, Kuster M, Dutly F et al. 1999 Whipple endocarditis without overt gastrointestinal disease: report of four cases. Ann Int Med 131, 112–116.
Harrison P, Marwah SS, Hughes RT, Bereford D. 1994 Non-transferrin bound iron and neutropenia after cytotoxic chemotherapy. J Clin Pathol 47, 350–352.
Herrici AT. 1940 Characteristics of fungous diseases. J Bacteriol 39, 113–138.
Hicklin H, Verghese A, Alvarez S. 1987 Dysgonic fermenter 2 septicemia. Rev Infec Dis 9, 884–890.
Hor L-I, Chang T-T, Wang S-T. 1999 Survival of Vibrio vulnificus in whole blood frompatients with chronic liver diseases: association with phagocytosis by neutrophils and serum ferritin levels. J Infec Dis 179, 275–278.
Horwitz MA. 1992 Interactions between macrophages and Legionella pneumophila. Curr Top Microbiol Immunol 181, 265–282.
Howe D, Mallavia LP. 1999Coxiella burnetii infection increases transferrin receptors on J774A.1 cells. Infec Immun 67, 3236–3241.
Linkous DA, Oliver JD. 1999 Pathogenesis of Vibrio vulnificus. FEMS Microbiol Lett 174, 207–214.
McGowan SE, Murray JJ, Parrish MG. 1986 Iron binding, internalization, and fate in humanalveolar macrophages. J Lab Clin Med 108, 587–595.
Morris JG Jr, Wright AC, Simpson LM, Wood PK, Johnson DE, Oliver JD. 1987 Virulence ofVibrio vulnificus: association with utilization of transferrin-bound iron, and lack of correlation with levels of cytotoxin or protease production. FEMS Microbiol Lett 40, 55–59.
Olivieri NF. The _-thalassemias. N Engl J Med 341, 99–109.
Parkin JD, Rush B, De Groot RJ, Budd RS. 1974 Iron absorption after splenectomy in hereditary spherocytosis. Aust NZ J Med 4, 58–61.
Pers C, Gahrn-Hansen B, Frederiksen W. 1996 Capnocytophaga canimorsus septicemia inDenmark, 1982–1995: review of 39 cases. Clin Infec Dis 23, 71–75.
Pootrakul P, Rugiatsakui R, Wasi P. 1980 Increased transferrin iron saturation in splenectomized thalassemic patients. Br J Haematol 46, 143–145.
Pope CD, O'Connell WA, Cianciotto NP. 1996 Legionella pneumophila mutants that aredefective for iron acquistion and assimilation and intracellular infection. Infec Immun 64, 629–636.
Quinn FD, Weinberg ED. 1988 Killing of Legionella pneumophila by human serum and iron-binding agents. Curr Microbiol 17,111–116.
Raja KB, Pountney D, Bomford A et al. 1996 A duodenal mucosal abnormality in the reductionof Fe (III) in patients with genetic haemochromatosis. Gut 38, 765–769.
Schoeden G, Goldenberger D, Forrer R et al. 1997 Deactivation of macrophages withinterleukin-4 is the key to the isolation of Tropheryma whippelii. J Infec Dis 176, 672–677.
Shapiro RL, Altekruse S, Hutwagner L et al. 1998 The role of Gulf Coast oysters harvested inwarmer months in Vibrio vulnifi-cus infections in the United States, 1988–1996. J InfecDis 178, 752–759.
Singer R. 1998 Diagnosis and treatment of Whipple's disease. Drugs 55, 699–704.
Street S, Donoghue HD, Neild GH. 1999 Thopheryma whippelii DNA in saliva of healthy people. The Lancet 354, 1178–1179.
Vadillo M, Corbella X, Pac V, Fernandez-Viladrich P, Rujol R. 1994 Multiple liver abscessesdue to Yersinia enterocolitica discloses primary hemochromatosis: three case reports andreview. Clin Infec Dis 18, 938–941.
Weinberg ED. 1987 DF-2 sepsis: a sequela of sidermia? Med Hypoth 24, 287–289.
Weinberg ED. 1999a Iron loading and disease surveillance. Emerg Infec Dis 5, 346–352.
Weinberg ED. 1999b the development of awareness of the carcinogenic hazard of inhaled iron. Oncol Res 11, 109–113.
Weinberg ED. 2000 Modulation of intra-macrophage iron metabolism during microbial cell invasion. Micr Infec, in press.
Weiss G, Bogdan C, Hentze MW. 1997 Pathways for the regulation of macrophage iron metabolism by the anti-inflammatury cytokines IL-4 and IL-13. J Immunol 158, 420–425.
Wesselius LJ, Flowers CH, Skikne BS. 1992 Alveolar macrophage content of isoferritins and transferrin. Am Rev Resp Dis 145, 311–316.
Witte DL, Crosby WH, Fairbanks VF, Mitros FA. 1996 Hereditary hemochromatosis. Clin Chim Acta 245, 139–200.
Wright AC, Simpson LM, Oliver JD. 1981 Role of iron in the pathogenesis of Vibrio vulnificus infections. Infec Immun 34, 503–507.
Yu VL. Legionella Pneumonia (Legionairre's disease). In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases, 4th edit. New York: Churchill Livingstone: 2087–2097.
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Weinberg, E. Microbial pathogens with impaired ability to acquire host iron. Biometals 13, 85–89 (2000). https://doi.org/10.1023/A:1009293500209
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DOI: https://doi.org/10.1023/A:1009293500209