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Effect of Hydrogen Peroxide on the Viscosity of a Hydroxyethylcellulose-Based Gel

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REFERENCES

  1. E. Azaz, M. Donbrow, and R. Hamburger. Incompatibility of nonionic surfactants with oxidizable drugs. Pharm. J. 211:5723–5723 (1973).

    Google Scholar 

  2. D. M. Johnson and W. F. Taylor. Degradation of fenprostalene in polyethylene glycol 400 solution. J. Pharm. Sci. 73:1414–1417 (1984).

    Google Scholar 

  3. J. W. McGinity, J. A. Hill, and A. L. LaVia. Influence of peroxide impurities in polyethylene glycols on drug stability. J. Pharm. Sci. 64:356–357 (1975).

    Google Scholar 

  4. D. S. Bindra, T. D. Williams, and V. J. Stella. Degradation of O6-Benzylguanine in aqueous polyethylene glycol 400 (PEG 400) solutions: Concerns with formaldehyde in PEG 400. Pharm. Res. 11:1060–1064 (1994).

    Google Scholar 

  5. B. J. Tyler and B. D. Ratner. Oxidative degradation of Biomer fractions prepared by using preparative-scale gel permeation chromatography. J. Biomater. Sci. Polymer Edn. 6:359–373 (1994).

    Google Scholar 

  6. N. S. Allen, M. Edge, and T. S. Jewitt. Degradation and stabilization of cellulose triacetate base motion picture film. J. Imaging Sci. and Tech. 36:4–12 (1992).

    Google Scholar 

  7. H. Winters and M. Goll. Nonenzymatic oxidative degradation of hydroxyethyl cellulose thickened latex paints. Journal of Coatings Technology 48:80–85 (1976).

    Google Scholar 

  8. V. L. Irwin and M. M. Williams. Viscosity loss in hydroxyethylcellulose thickened latex paints caused by chemical oxidants: Method of detection. Journal of Coatings Technology 52:71–74 (1976).

    Google Scholar 

  9. European Patent Application, High Solids Low Viscosity Polysaccharide Composition, No. 0465992 A1. Aqualon Co., February 7, 1991.

  10. Assay for Oxidizing Substances Present in Propylene Glycol, BP, 1993, Vol. 1, HMSO, London, p. 556.

  11. The method using potassium permanganate titration described in USP (Monograph for Hydrogen Peroxide Concentrate, USP 23, 1995, Rand McNally, Taunton, MA, p. 767) is not suitable for the gel system, since the permanganate is able to oxidize the organic components present in the gel.

  12. L. F. McBurney. Degradation of cellulose. In E. Ott, H. M. Spurlin, and M. W. Grafflin (eds.), Cellulose and Cellulose Derivatives. Part I, Interscience, New York. 1954, p. 99.

    Google Scholar 

  13. E. M. Kuramshin, L. G. Kulak, M. N. Nazarov, S. S. Zlotskii, D. L. Rakhmankulov. Oxidation of cyclic acetals as a preparation method of diol monoester production. J. Prakt. Chem. 331:591–599 (1989).

    Google Scholar 

  14. P. M. Whitmore, J. Bogaard. Determination of the cellulose scission route in the hydrolytic and oxidation degradation of paper. Restaurator 15:26–45 (1994).

    Google Scholar 

  15. N. Yui, T. Okano, Y. Sakura. Inflammation responsive degradation of crosslinked hyaluronic acid gels. J. Controlled Release 22:105–116 (1992).

    Google Scholar 

  16. Monograph for Butylated Hydroxyanisole (BHA). In A. Wade and P. J. Weller (eds), Handbook of Pharmaceutical Excipients, 2nd Ed., American Pharmaceutical Association and the Pharmaceutical Press, 1994, p. 45.

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Dahl, T., He, GX. & Samuels, G. Effect of Hydrogen Peroxide on the Viscosity of a Hydroxyethylcellulose-Based Gel. Pharm Res 15, 1137–1140 (1998). https://doi.org/10.1023/A:1011958901154

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