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Creatine supplementation during college football training does not increase the incidence of cramping or injury

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Abstract

The purpose of this study was to examine the effects of creatine supplementation on the incidence of injury observed during 3-years of NCAA Division IA college football training and competition. In an open label manner, athletes participating in the 1998–2000 football seasons elected to take creatine or non-creatine containing supplements following workouts/practices. Subjects who decided to take creatine were administered 15.75 g of creatine for 5 days followed by ingesting an average of 5 g/day thereafter administered in 5–10 g doses. Creatine intake was monitored and recorded by research assistants throughout the study and ranged between 34–56% of players during the course of the study. Subjects practiced or played in environmental conditions ranging from 8–40°C (mean 24.7 ± 9°C) and 19–98% relative humidity (49.3 ± 17%). Injuries treated by the athletic training staff were recorded and categorized as cramping, heat/dehydration, muscle tightness, muscle strains/pulls, non-contact joint injuries, contact injuries, and illness. The number of missed practices due to injury/illness was also recorded. Data are presented as the total number of treated injuries for creatine users/total injuries observed and percentage occurrence rate of injuries for creatine users for all seasons. The incidence of cramping (37/96, 39%), heat/dehydration (8/28, 36%), muscle tightness (18/42, 43%), muscle pulls/strains (25/51, 49%), non-contact joint injuries (44/132, 33%), contact injuries (39/104, 44%), illness (12/27, 44%), number of missed practices due to injury (19/41, 46%), players lost for the season (3/8, 38%), and total injuries/missed practices (205/529, 39%) were generally lower or proportional to the creatine use rate among players. Creatine supplementation does not appear to increase the incidence of injury or cramping in Division IA college football players.

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References

  1. Williams MH, Kreider R, Branch JD: Creatine: In: The Power Supplement. Human Kinetics Publishers, Champaign, IL, 1999

    Google Scholar 

  2. Kreider R: Creatine supplementation: Analysis of ergogenic value, medical safety, and concerns. J Exerc Physiol Online 1: 7-18, 1998. Available: http://www.css.edu/users/tboone2/asep/jan3.htm

    Google Scholar 

  3. Kraemer WJ, Volek JS: Creatine supplementation. Its role in human performance. Clin Sports Med 18: 651-666, 1999

    Google Scholar 

  4. Terjung RL, Clarkson P, Eichner ER, Greenhaff PL, Hespel PJ, Israel RG, Kraemer WJ, Meyer RA, Spriet LL, Tarnopolsky MA, Wagenmakers AJ, Williams MH: American College of Sports Medicine roundtable. The physiological and health effects of oral creatine supplementation. Med Sci Sports Exerc 32: 706-717, 2000

    Google Scholar 

  5. Vandenberghe K, Goris M, Van Hecke P, Van Leemputte M, Vangerven L, Hespel P: Long-term creatine intake is beneficial to muscle performance during resistance training. J Appl Physiol 83: 2055-2063, 1997

    Google Scholar 

  6. Guerrero-Ontiveros ML, Wallimann T: Creatine supplementation in health and disease. Effects of chronic creatine ingestion in vivo: Down-regulation of the expression of creatine transporter isoforms in skeletal muscle. Mol Cell Biochem 184: 427-437, 1998

    Google Scholar 

  7. Tarnopolsky MA, Parise G, Fu MH, Brose A, Mahoney D, Wallimann T: Creatine monohydrate supplementation at the recommended dosage does not affect creatine transporter content during resistance exercise training in either the young or the elderly. Paper presented at the 6th International Conference on Guanidino Compounds in Biology and Medicine, Cincinatti, OH, September 3, 2001

  8. Kuehl K, Soehler S, Kulacki K, Goldberg L, Elliot D, Bennett W, Haddock B: Effects of oral creatine monohydrate supplementation on renal function in adults. Med Sci Sports Exerc 32: S168, 2000

    Google Scholar 

  9. Kreider R, Ransom J, Rasmussen C, Hunt J, Melton C, Stroud T, Cantler E, Milnor P: Creatine supplementation during pre-season football training does not affect markers of renal function. FASEB J 13: A543, 1999

    Google Scholar 

  10. Kreider R, Melton C, Rasmussen C, Greenwood M, Lancaster S, Cantler E, Milnor P, Almada AL: Effects of long-term creatine supplementation on renal function and muscle and liver enzyme efflux. Med Sci Sports Exerc 33: S207, 2001

    Google Scholar 

  11. Rasmussen C, Kreider R, Melton C, Ransom J, Stroud T, Cantler E, Greenwood M, Milnor P: Long-term creatine supplementation during football training does not affect markers of renal stress. J Strength Cond Res 13: 431, 1999

    Google Scholar 

  12. Almada AL, Kreider R, Melton C, Rasmussen C, Lundberg J, Ransom J, Greenwood M, Stroud T, Cantler E, Milnor P, Fox J: Long-term creatine supplementation does not affect markers of renal stress in athletes. J Strength Cond Res 14: 359, 2000

    Google Scholar 

  13. Robinson TM, Sewell DA, Casey A, Steenge G, Greenhaff PL: Dietary creatine supplementation does not affect some haematological indices, or indices of muscle damage and hepatic and renal function. Br J Sports Med 34: 284-288, 2000

    Google Scholar 

  14. Poortmans JR, Francaux M: Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc 31: 1108-1110, 1999

    Google Scholar 

  15. Poortmans JR, Auquier H, Renaut V, Durussel A, Saugy M, Brisson GR: Effect of short-term creatine supplementation on renal responses in men. Eur J Appl Physiol Occup Physiol 76: 566-567, 1997

    Google Scholar 

  16. Ransom J, Kreider R, Hunt J, Melton C, Rasmussen C, Stroud T, Cantler E, Milnor P: Effects of creatine supplementation during training on markers of catabolism and muscle and liver enzymes. Med Sci Sports Exerc 31: S265, 1999

    Google Scholar 

  17. Ransom J, Kreider R, Rasmussen C, Melton C, Stroud T, Cantler E, Greenwood M, Milnor P: Effects of long-term creatine supplementation during training on markers of catabolism and enzyme efflux. J Str Cond Res 13: 431, 1999

    Google Scholar 

  18. Schilling BK, Stone MH, Utter A, Kearney JT, Johnson M, Coglianese R, Smith L, O'Bryant HS, Fry AC, Starks M, Keith R, Stone ME: Creatine supplementation and health variables: A retrospective study. Med Sci Sports Exerc 33: 183-188, 2001

    Google Scholar 

  19. Kreider RB, Ferreira M, Wilson M, Grindstaff P, Plisk S, Reinardy J, Cantler E, Almada AL: Effects of creatine supplementation on body composition, strength, and sprint performance. Med Sci Sports Exerc 30: 73-82, 1998

    Google Scholar 

  20. Rasmussen C, Kreider R, Ransom J, Hunt J, Melton C, Stroud T, Cantler E, Milnor P: Creatine supplementation during pre-season football training does not affect fluid or electrolyte status. Med Sci Sports Exerc 31: S299, 1999

    Google Scholar 

  21. Hulver MW, Campbell A, Haff G, Schroeder C, Comeau M, Potteiger JA: The effects of creatine supplementation on total body fluids, performance, and muscle cramping during exercise. Med Sci Sports Exerc 32: S133, 2000

    Google Scholar 

  22. Oopik V, Paasuke M, Timpmann S, Medijainen L, Ereline J, Smirnova T: Effect of creatine supplementation during rapid body mass reduction on metabolism and isokinetic muscle performance capacity. Eur J Appl Physiol Occup Physiol 78: 83-92, 1998

    Google Scholar 

  23. Volek JS, Mazzetti SA, Farquhar WB, Barnes BR, Gomez, AI, Kraemer WJ: Physiological responses to short-term exercise in the heat after creatine loading. Med Sci Sports Exerc 33: 1101-1108, 2001

    Google Scholar 

  24. Mihic S, MacDonald JR, McKenzie S, Tarnopolsky MA: Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. Med Sci Sports Exerc 32: 291-296, 2000

    Google Scholar 

  25. Peeters BM, Lantz CD, Mayhew JL: Effect of oral creatine monohydrate and creatine phosphate supplementation on maximal strength indices, body composition, and blood pressure. J Strength Cond Res 13: 3-9, 1999

    Google Scholar 

  26. Earnest CP, Snell P, Rodriguez R, Almada A, Mitchell TL: The effect of creatine monohyerate ingestion on anaerobic power indices, muscular strength and body composition. Acta Physiol Scand 153: 207-209, 1995

    Google Scholar 

  27. Earnest CP, Almada A, Mitchell TL: High-performance capillary electrophoresis-pure creatine monohydrate reduced blood lipids in men and women. Clinical Science 91: 113-118, 1996

    Google Scholar 

  28. Bemben MG, Bemben DA, Loftiss DD, Knehans AW: Creatine supplementation during resistance training in college football athletes. Med Sci Sports Exerc 33: 1667-1673, 2001

    Google Scholar 

  29. Bermon S, Venembre P, Sachet C, Valour S, Dolisi C: Effects of creatine monohydrate ingestion in sedentary and weight-trained older adults. Acta Physiol Scand 164: 147-155, 1998

    Google Scholar 

  30. Eijnde BO, Hespel P: Short-term creatine supplementation does not alter the hormonal response to resistance training. Med Sci Sports Exerc 33: 449-453, 2001

    Google Scholar 

  31. Greenwood M, Kreider R, Melton C, Rasmussen C, Lundberg J, Stroud T, Cantler E, Milnor P, Almada AL: Short-and long-term creatine supplementation does not affect hematological markers of health. J Strength Cond Res 14: 362-363, 2000

    Google Scholar 

  32. Hespel P, Eijnde BO, Van Leemputte M, Urso B, Greenhaff PL, Labarque V, Dymarkowski S, Van Hecke P, Richter EA: Oral creatine supplementation facilitates the rehabilitation of disuse atrophy and alters the expression of muscle myogenic factors in humans. J Physiol 536: 625-633, 2001

    Google Scholar 

  33. Kreider R, Rasmussen C, Melton C, Greenwood M, Stroud T, Ransom J, Cantler E, Milnor P, Almada AL: Long-term creatine supplementation does not adversely affect clinical markers of health. Med Sci Sports Exerc 32: S134, 2000

    Google Scholar 

  34. Stone MH, Schilling BK, Fry AC, Johnson M, Keith RE, Kearney JT, Coglianese RH, Stone ME, Utter A, Smith L, O'Bryant HS: A retrospective study of long-term creatine supplementation on blood markers of health. J Strength Cond Res 13: 433, 1999

    Google Scholar 

  35. Sipila I, Rapola J, Simell O, Vannas A: Supplementary creatine as a treatment for gyrate atrophy of the choroid and retina. New Engl J Med 304: 867-870, 1981

    Google Scholar 

  36. Vannas-Sulonen K, Sipila I, Vannas A, Simell O, Rapola J: Gyrate atrophy of the choroid and retina. A five-year follow-up of creatine supplementation. Ophthalmology 92: 1719-1727, 1985

    Google Scholar 

  37. Greenwood M, Farris J, Kreider R, Greenwood L, Byars A: Creatine supplementation patterns and perceived effects in select division I collegiate athletes. Clin J Sport Med 10: 191-194, 2000

    Google Scholar 

  38. Juhn MS, O'Kane JW, Vinci DM: Oral creatine supplementation in male collegiate athletes: A survey of dosing habits and side effects. J Am Diet Assoc 99: 593-595, 1999

    Google Scholar 

  39. LaBotz M, Smith BW: Creatine supplement use in an NCAA Division I athletic program. Clin J Sport Med 9: 167-169, 1999

    Google Scholar 

  40. Juhn MS, Tarnopolsky M: Potential side effects of oral creatine supplementation: A critical review. Clin J Sport Med 8: 298-304, 1998

    Google Scholar 

  41. Ziegenfuss TN, Lowery LM, Lemon PWR: Acute fluid volume changes in men during three days of creatine supplementation. J Exerc Physiol Online 1: 1-9, 1998. Available: http://www.css.edu/users/tboone2/asep/jan3.htm

    Google Scholar 

  42. Kern M, Podewils LJ, Vukovich M, Buono MJ: Physiological response to exercise in the heat following creatine supplementation. J Exerc Physiol Online 4: 18-27, 2001. Available: http://www.css.edu/users/tboone2/asep/Kern.pdf

    Google Scholar 

  43. Papadopoulos C, Imamura R, Bandon LJ: The effect of creatine supplementation on repeated bouts of high-intensity exercise in the heat. Med Sci Sports Exerc 33: S203, 2001

    Google Scholar 

  44. Greenwood M, Kreider R, Rasmussen C, Ransom J, Melton C, Stroud T, Cantler E, Milnor P: Creatine supplementation does not increase incidence of cramping or injury during college football training II. J Strength Cond Res 13: 425-426, 1999

    Google Scholar 

  45. Greenwood M, Greenwood LD, Kreider R, Byars A: Effects of creatine supplementation on the incidence of cramping/injury during college football three a day training. Med Sci Sports Exerc 32: S136, 2000

    Google Scholar 

  46. Greenwood LD, Greenwood M, Kreider R, Byars A: Effects of creatine supplementation on the incidence of cramping/injury during collegiate fall baseball. Med Sci Sports Exerc 32: S136, 2000

    Google Scholar 

  47. Hunt J, Kreider R, Melton C, Ransom J, Rasmussen C, Stroud T, Cantler E, Milnor P: Creatine does not increase incidence of cramping or injury during pre-season college football training II. Med Sci Sports Exerc 31: S355, 1999

    Google Scholar 

  48. Kreider R, Rasmussen C, Ransom J, Almada AL: Effects of creatine supplementation during training on the incidence of muscle cramping, injuries and GI distress. J Strength Cond Res 12: 275, 1998

    Google Scholar 

  49. Kreider R, Melton C, Ransom J, Rasmussen C, Stroud T, Cantler E, Greenwood M, Milnor P: Creatine supplementation does not increase incidence of cramping or injury during college football training I. J Strength Cond Res 13: 428, 1999

    Google Scholar 

  50. Kreider R, Melton C, Hunt J, Rasmussen C, Ransom J, Stroud T, Cantler E, Milnor P: Creatine does not increase incidence of cramping or injury during pre-season college football training I. Med Sci Sports Exerc 31: S355, 1999

    Google Scholar 

  51. Ortega Gallo PA, Dimeo F, Batista J, Bazan F, Betchakian L, Garcia Cambon C, Griffa J: Creatine supplementation in soccer players, effects in body composition and incidence of sport-related injuries. Med Sci Sports Exerc 32: S134, 2000

    Google Scholar 

  52. Greenwood M, Kreider R, Greenwood LD, Comeau M, Brown LE, Stahura K, Byars A: Perceived health status and side-effects associated with creatine supplementation during the collegiate baseball season. Med Sci Sports Exerc 33: S205, 2001

    Google Scholar 

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Authors and Affiliations

  1. Human Performance Laboratory, Department of HPESS, Arkansas State University, Jonesboro, AR, 72467, USA

    Michael Greenwood

  2. Exercise and Sport Nutrition Laboratory, Department of HMSE, University of Memphis, Memphis, TN, 38152-3480, USA

    Richard B. Kreider, Charlie Melton, Stacy Lancaster & Edward Cantler

  3. Exercise and Sport Nutrition Laboratory, Department of Health, Human Performance, and Recreation, Waco, TX, USA

    Richard B. Kreider & Christopher Rasmussen

  4. The Milnor Clinic, 920 Estate, Suite 8, Memphis, TN, 38119, USA

    Purvis Milnor

  5. MetaResponse Sciences, Inc., 30131 Town Center Drive, #211, Laguna Niguel, CA, 92677, USA

    Anthony Almada

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Greenwood, M., Kreider, R.B., Melton, C. et al. Creatine supplementation during college football training does not increase the incidence of cramping or injury. Mol Cell Biochem 244, 83–88 (2003). https://doi.org/10.1023/A:1022413202549

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