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Genetic and cellular mechanisms in chromium and nickel carcinogenesis considering epidemiologic findings

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Abstract

Genetic and environmental interactions determine cancer risks but some cancer incidence is primarily a result of inherited genetic deficits alone. Most cancers have an occupational, viral, nutritional, behavioral or iatrogenic etiology. Cancer can sometimes be controlled through broad public health interventions including industrial hygiene and engineering controls. Chromium and nickel are two human carcinogens associated with industrial exposures where public health measures apparently work. Carcinogenic mechanisms of these metals are examined by electron-spin-resonance-spectroscopy and somatic-mutation-and-recombination in Drosophila melanogaster in this report. Both metals primarily affect initiation processes in cancer development suggesting important theoretical approaches to prevention and followup.

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Authors and Affiliations

  1. National Center for Environmental Assessment, Office of Research and Development, US Environmental Protection Agency, Washington, DC, 20460, USA

    Arthur Chiu

  2. Department of Biological Sciences, Illinois State University, Normal, IL, 61761, USA

    A.J. Katz

  3. Office of Prevention, Pesticides and Toxic Substances, US Environmental Protection Agency, Washington, DC, 20460, USA

    Jefferson Beaubier

  4. Office of Science and Technology, Office of Water, US Environmental Protection Agency, Washington, DC, 20460, USA

    Nancy Chiu

  5. Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, 26505, USA

    Xianglin Shi

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Chiu, A., Katz, A., Beaubier, J. et al. Genetic and cellular mechanisms in chromium and nickel carcinogenesis considering epidemiologic findings. Mol Cell Biochem 255, 181–194 (2004). https://doi.org/10.1023/B:MCBI.0000007274.25052.82

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