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Originalia

Contingent Negative Variation (CNV) bei Kindern mit hyperkinetischem Syndrom - eine experimentelle Untersuchung mittels des Continuous Performance Test (CPT)

Published Online:September 01, 2006https://doi.org/10.1024//1422-4917.28.4.239

Abstract

ZusammenfassungFragestellung: Gibt es neurophysiologische Korrelate der Aufmerksamkeitsstörung beim hyperkinetischen Syndrom (HKS) und welche Bedeutung haben diese für die Ätiologie der Störung. Methodik: Selektive Aufmerksamkeitsprozesse wurden anhand des zweistufigen Continuous Performance Test (CPT) bei 18 Jungen mit hyperkinetischem Syndrom (HKS) untersucht und mit einer nach dem Alter parallelisierten Kontrollgruppe von 21 Jungen verglichen. Die Altersspanne der Stichprobe betrug 6 bis 12 Jahre. Parallel dazu wurden ereigniskorrelierte Potentiale (EKP) während des Tests an den Elektrodenpositionen Fz, Cz, Pz und Oz mit Referenz zu verbundenen Ohren abgeleitet. Ergebnisse: Im EKP nach dem präparatorischen Stimulus konnten zwei Komponenten der Contingent Negative Variation (CNV) mit unterschiedlicher topographischer Verteilung identifiziert werden (CNV-1: 600 bis 1100 ms und CNV-2: 1000 bis 1500 ms nach Stimulus). Die Stichproben unterschieden sich nicht auf der Verhaltensebene (Fehlerrate und Reaktionszeit). Signifikante Gruppenunterschiede ergaben sich hinsichtlich der Topographie der beiden CNV-Komponenten. Kinder mit HKS zeigten im Vergleich zu Kontrollkindern eine signifikant niedrigere CNV-1 über der frontalen und eine Tendenz zu stärkerer Negativierung (CNV-1 und CNV-2) über der occipitalen Elektrode. Schlussfolgerungen: Die Ergebnisse unterstützen die Hypothese einer Unterfunktion frontaler inhibitorischer Prozesse bei Kindern mit HKS.


Contingent Negative Variation (CNV) in Children with Attention Deficit / Hyperactivity Disorder - An Experimental Study Using the Continuous Performance Test (CPT)

SummaryObjectives: Evaluation of event-related potentials for selective attention in attention deficit/hyperactivity disordered children. Methods: Selective attention processes were examined in a group of 18 boys aged 6 to 12 years with attention deficit / hyperactivity disorder and compared with the data of a control group of 21 age and sex matched boys. Parallel thereto the event-related potentials (ERP) were derived during the test at the electrode positions Fz, Cz, Pz, and Oz with reference to the linked ears. Results: Two components of the contingent negative variation (CNV) with different topography were identified in the ERP following a preparatory stimulus (CNV-1: 600 to 1100 ms and CNV-2: 1000 to 1500 ms after the stimulus). There were no group differences at the behavioural level (number of correct detected targets, number of errors). Significant group differences resulted with regard to the topography of the two CNV components. Children with ADD showed an attenuated frontal CNV-1 amplitude and a trend towards increased CNV-1 and CNV-2 occipital amplitudes. Conclusions: The results support the hypothesis of impaired frontal inhibitory processes in children with ADD.

Literatur

  • Amen, D.G. , Carmichael, B.D. High-resolution brain SPECT imaging in ADHD. Annals of Clinical Psychiatry, 9, 81– 86 (1997). First citation in articleCrossref Medline, Google Scholar

  • Aydin, C. , Idiman, F. , Idiman, E. Contingent negative variation in normal children and in children with attention deficit disorder. Advances in Biological Psychiatry, 16, 178– 190 (1987). First citation in articleCrossref, Google Scholar

  • Brunia, C.H.M. Waiting in Readiness - Gating in Attention and Motor Preparation. Psychophysiology, 30, 327– 339 (1993). First citation in articleCrossref Medline, Google Scholar

  • Brunia, C.H.M. , Damen, E.J.P. , Böcker, K.B.E. Expectancy revisited. Brain Topography, 5, 429– 433 (1993). First citation in articleCrossref Medline, Google Scholar

  • Conners, C.K. Rating scales for use in drug studies with children. Psychopharmacological Bulletin, 9, 24– 84 (1973). First citation in articleGoogle Scholar

  • Dumais-Huber, C. , Rothenberger, A. Psychophysiological correlates of orienting, anticipation and contingency changes in children with psychiatric disorders. Journal of Psychophysiology, 6, 225– 239 (1992). First citation in articleGoogle Scholar

  • Duncan, C.C. , Rumsey, J.M. , Wilkniss, S.M. , Denckla, M.B. , Hamburger, S.D. , Odou-Potkin, M. Developmental dyslexia and attention dysfunction in adults: Brain potential indices of information processing. Psychophysiology, 31, 386– 401 (1994). First citation in articleCrossref Medline, Google Scholar

  • Hansen, J.C. , Hillyard, S.A. Endogeneous brain potentials associated with selective auditory attention. Electroencephalography and Clinical Neurophysiology, 49, 277– 290 (1980). First citation in articleCrossref Medline, Google Scholar

  • Holcomb, P.J. , Ackerman, P.T. , Dykman, R.A. Auditory event-related potentials in attention and reading disabled boys. International Journal of Psychophysiology, 3, 263– 273 (1986). First citation in articleCrossref Medline, Google Scholar

  • Johnstone, S.J. , Barry, R.J. Auditory event-related potentials to a two-tone discrimination paradigm in attention deficit hyperactivity disorder. Psychiatry Research, 64, 179– 192 (1996). First citation in articleCrossref Medline, Google Scholar

  • Jonkman, L.M. , Kemner, C. , Verbaten, M.N. , Koelega, H.S. , Camfferman, G. , v.d.-Gaag, R.J. , Buitelaar, J.K. , van-Engeland, H. Effects of methylphenidate on event-related potentials and performance of attention-deficit hyperactivity disorder children in auditory and visual selective attention tasks. Biological Psychiatry, 41, 690– 702 (1997a). First citation in articleCrossref Medline, Google Scholar

  • Jonkman, L.M. , Kemner, C. , Verbaten, M.N. , Koelega, H.S. , Camfferman, G. , v.d.-Gaag, R.J. , Buitelaar, J.K. , van-Engeland, H. Event-related potentials and performance of attention-deficit hyperactivity disorder: children and normal controls in auditory and visual selective attention tasks. Biological Psychiatry, 41, 595– 611 (1997b). First citation in articleCrossref Medline, Google Scholar

  • Kemner, C. , Verbaten, M.N. , Koelega, H.S. , Buitelaar, J.K. , van-der-Gaag, R.J. , Camfferman, G. , van-Engeland, H. Event-related brain potentials in children with attention-deficit and hyperactivity disorder: effects of stimulus deviancy and task relevance in the visual and auditory modality. Biological Psychiatry, 40, 522– 534 (1996). First citation in articleCrossref Medline, Google Scholar

  • Klorman, R. , Brumaghim, J.T. , Salzman, L.F. , Strauss, J. , Borgstedt, A.D. , McBride, M.C. , Loeb, S. Effects of methylphenidate on attention-deficit hyperactivity disorder with and without aggressive/noncompliant features. Journal of Abnormal Psychology, 97, 413– 422 (1988). First citation in articleCrossref Medline, Google Scholar

  • Klorman, R. , Brumaghim, J.T. , Fitzpatrick, P.A. , Borgstedt, A.D. , Strauss, J. Clinical and cognitive effects of methylphenidate on children with attention deficit disorder as a function of aggression/oppositionality and age. Journal of Abnormal Psychology, 103, 206– 221 (1994). First citation in articleCrossref Medline, Google Scholar

  • Kuperman, S. , Johnson, B. , Arndt, S. , Lindgren, S. , Wolraich, M. Quantitative EEG differences in a nonclinical sample of children with ADHD and undifferentiated ADD. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 1009– 1017 (1996). First citation in articleCrossref Medline, Google Scholar

  • Lazzaro, I. , Anderson, J. , Gordon, E. , Clarke, S. , Leong, J. , Meares, R. Single trial variability within the P300 (250-500 ms) processing window in adolescents with attention deficit hyperactivity disorder. Psychiatry Research, 73, 91– 101 (1997). First citation in articleCrossref Medline, Google Scholar

  • Loiselle, D.L. , Stamm, J.S. , Maitinsky, S. , Whipple, S.C. Evoked potential and behavioral signs of attentive dysfunctions in hyperactive boys. Psychophysiology, 17, 193– 201 (1980). First citation in articleCrossref Medline, Google Scholar

  • Mirsky, A.F. , Kornetzky, C. On the dissimilar effects of drugs on the Digit Symbol Substitution and Continuous Performance Tests: a review and preliminary integration of behavioral and physiological evidence. Psychopharmacologia, 5, 161– 177 (1964). First citation in articleCrossref Medline, Google Scholar

  • Näätänen, R. , Michie, P.T. Early selective attention effects on the evoked potential: a critical review and reinterpretation. Biological Psychology, 8, 81– 136 (1979). First citation in articleCrossref Medline, Google Scholar

  • Näätänen, R. , Paavilainen, P. , Reinikainen, K. Do Event-Related Potentials to Infrequent Decrements in Duration of Auditory Stimuli Demonstrate a Memory Trace in Man. Neuroscience Letters, 107, 347– 352 (1989). First citation in articleCrossref Medline, Google Scholar

  • Newton, J.E. , Oglesby, D.M. , Ackerman, P.T. , Dykman, R.A. Visual slow brain potentials in children with attention deficit disorder. Integrative Physiological and Behavioral Science, 29, 39– 54 (1994). First citation in articleCrossref Medline, Google Scholar

  • Oades, R.D. , Dittmann-Balcar, A. , Schepker, R. , Eggers, C. , Zerbin, D. Auditory event-related potentials (ERPs) and mismatch negativity (MMN) in healthy children and those with attention-deficit or tourette/tic symptoms. Biological Psychology, 43, 163– 185 (1996). First citation in articleCrossref Medline, Google Scholar

  • Raine, A. , Venables, P.H. Contingent negative variation, P3 evoked potentials, and antisocial behavior. Psychophysiology, 24, 191– 199 (1987). First citation in articleCrossref Medline, Google Scholar

  • Rapoport, J.L. , Buchsbaum, M.S. , Weingartner, H. , Zahn, T.P. , Ludlow, C. , Mikkelsen, E.J. Dextroamphetamine. Its cognitive and behavioral effects in normal and hyperactive boys and normal men. Archives of General Psychiatry, 37, 933– 943 (1980). First citation in articleCrossref Medline, Google Scholar

  • Rösler, F. , Heil, M. Toward a Functional Categorization of Slow Waves - Taking into Account Past and Future Events. Psychophysiology, 28, 344– 358 (1991). First citation in articleCrossref Medline, Google Scholar

  • Rosvold, H.E. , Mirsky, A.F. , Sarason, I. , Bransome, E.D.J. , Beck, L.H. A continuous performance test of brain damage. Journal of Consulting Psychology, 20, 343– 350 (1956). First citation in articleCrossref Medline, Google Scholar

  • Sangal, J.M. , Sangal, R.B. , Persky, B. Abnormal auditory P300 topography in attention deficit disorder predicts poor response to pemoline. Clinical Electroencephalography, 26, 204– 213 (1995). First citation in articleCrossref Medline, Google Scholar

  • Strandburg, R.J. , Marsh, J.T. , Brown, W.S. , Asarnow, R.F. , Higa, J. , Harper, R. , Guthrie, D. Continuous-processing - related event-related potentials in children with attention deficit hyperactivity disorder. Biological Psychiatry, 40, 964– 980 (1996). First citation in articleCrossref Medline, Google Scholar

  • Sunohara, G.A. , Voros, J.G. , Malone, M.A. , Taylor, M.J. Effects of methylphenidate in children with attention deficit hyperactivity disorder: a comparison of event-related potentials between medication responders and non-responders. International Journal of Psychophysiology, 27, 9– 14 (1997). First citation in articleCrossref Medline, Google Scholar

  • Sutton, S. , Braren, M. , Zubin, J. , John, E.R. Evoked potential correlates of stimulus uncertainty. Science, 150, 1187– 1188 (1965). First citation in articleCrossref Medline, Google Scholar

  • van Leeuwen, T.H. , Steinhausen, H.C. , Overtoom, C.C. , Pascual-Marqui, R.D. , van't Klooster, B. , Rothenberger, A. , Sergeant, J.A. , Brandeis, D. The continuous performance test revisited with neuroelectric mapping: impaired orienting in children with attention deficits. Behavioural Brain Research, 94, 97– 110 (1998). First citation in articleCrossref Medline, Google Scholar

  • Walter, W.G. , Aldridge, V.G. , McCallum, W.C. , Winter, A.L. Contingent negative variation: an electric sign of sensorimotor association and expectancy in the human brain. Nature, 203, 380– 384 (1964). First citation in articleCrossref Medline, Google Scholar

  • Weate, S.J. , Newell, S.A. , Bogner, J.E. , Andrews, J.M. , Drake, M.E. Jr. Contingent negative variation in Gilles de la Tourette syndrome. Clinical Electroencephalography, 24, 188– 191 (1993). First citation in articleCrossref Medline, Google Scholar

  • Winsberg, B.G. , Javitt, D.C. , Silipo, G.S. , Doneshka, P. Mismatch negativity in hyperactive children: effects of methylphenidate. Psychopharmacology Bulletin, 29, 229– 233 (1993). First citation in articleMedline, Google Scholar

  • Winsberg, B.G. , Javitt, D.C. , Silipo, G.S. Electrophysiological indices of information processing in methylphenidate responders. Biological Psychiatry, 42, 434– 445 (1997). First citation in articleCrossref Medline, Google Scholar

  • Woestenburg, J.C. , Das-Smaal, E.A. , Brand, E. , Kramer, S. Learning during visual search in children with attentional and learning problems: A trial-to-trial evaluation of RT and ERP measures. Journal of Psychophysiology, 6, 204– 224 (1992). First citation in articleGoogle Scholar

  • Yordanova, J. , Dumais-Huber, C. , Rothenberger, A. , Woerner, W. Frontocortical activity in children with comorbidity of tic disorder and attention-deficit hyperactivity disorder. Biological Psychiatry, 41, 585– 594 (1997). First citation in articleCrossref Medline, Google Scholar

  • Zametkin, A.J. , Liebenauer, L.L. , Fitzgerald, G.A. , King, A.C. , Minkunas, D.V. , Herscovitch, P. , Yamada, E.M. , Cohen, R.M. Brain Metabolism in Teenagers with Attention-Deficit Hyperactivity Disorder. Archives of General Psychiatry, 50, 333– 340 (1993). First citation in articleCrossref Medline, Google Scholar