Abstract
DURING the past 3 years we have been investigating the biological properties of a series of thiophens of tho following general formula (I): in which R is an alkyl or alkoxy group and the substituent X is an electron-withdrawing group such as halogen or nitro. These investigations resulted from the observation that the compound I.C.I. 45,514 (I, R = ethoxy, X = H) prevented the development of secondary inflamed lesions in rats injected into the foot-pad with a fine suspension of dead tubercle bacilli in liquid paraffin. The use of this syndrome for evaluating chemotherapeutic agents has already been described1,2.
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References
Newbould, B. B., Brit. J. Pharmacol., 21, 127 (1963).
Newbould, B. B., Brit. J. Pharmacol., 24, 632 (1965).
O'Mant, D. M., and Stacey, G. J., U.K. patent application Nos. 8965/63 and 27696/63 (Belg. Pat. No. 661, 255).
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FRANKLIN, T., NEWBOULD, B., O'MANT, D. et al. A New Type of Cytotoxic Immunosuppressive Agent: 3-Acetyl-5-(4-fluorobenzylidene)4-hydroxy-2-oxo-2:5-dihydrothiophen. Nature 210, 638–639 (1966). https://doi.org/10.1038/210638a0
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DOI: https://doi.org/10.1038/210638a0
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