Abstract
The complete amino-acid sequences of the alpha chains of the common genetic variants of human haptoglobin confirm that the α2 chain has arisen by partial gene duplication of the Hp1 locus. A homology in sequence between a portion of the haptoglobin alpha chain sequence and a series of Bence Jones light chains suggests that the functional similarity between haptoglobin and immunoglobin G may reflect a common evolutionary origin.
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References
Smithies, O., Connell, G. E., and Dixon, G. H., Amer. J. Hum. Genet., 14, 14 (1962).
Smithies, O., Connell, G. E., and Dixon, G. H., J. Mol. Biol., 21, 213 (1966).
Smithies, O., Connell, G. E., and Dixon, G. H., Nature, 196, 232 (1962).
Dixon, G. H., Essays in Biochemistry, 2, 147 (Academic Press, New York and London, 1966).
Eck, R. V., and Dayhoff, M. O., Science, 152, 363 (1966).
Cantor, C. R., and Jukes, T. H., Proc. US Nat. Acad. Sci., 56, 177 (1966).
Fitch, W. M., J. Mol. Biol., 16, 17 (1966).
Hill, R. L., Delaney, R., Fellows, R. E., and Lebowitz, H. E., Proc. US Nat. Acad. Sci., 56, 1762 (1966).
Black, J. A., and Dixon, G. H., Nature, 216, 153 (1967).
Laurell, C. B., in Protides of the Biological Fluids, Proc. Sixth Colloquium Bruges, 1958 (edit. by Peeters, H.), 49 (Elsevier, Amsterdam, 1959).
Connell, G. E., Smithies, O., and Dixon, G. H., J. Mol. Biol., 21, 225 (1966).
Nance, W. E., and Smithies, O., Nature, 198, 869 (1963).
Parker, W. C., and Bearn, A. G., Ann. Hum. Genet., 25, 227 (1961).
Parker, W. C., thesis, Rockefeller Univ. (1963).
Cloarec, L., and Moretti, J., CR Acad. Sci., 262, 208 (1966).
Chan, G. F. Q., thesis, Univ. British Columbia (1968).
Waks, M., and Alfsen, A., Biochem. Biophys. Res. Commun., 23, 62 (1966).
Jayle, M. F., Bull. Soc. Chem. Biol., 33, 876 (1951).
Nakajima, H., Proc. Ninth Cong. Eur. Soc. Haematol., Lisbon, 840 (S. Karger, Basel, 1963).
Muirhead, H., and Perutz, M. F., Cold Spring Harbor Symp. Quant. Biol., 28, 451 (1963).
Nagel, R. L., Rothman, M. C., Bradly, T. B., and Ranney, H. M., J. Biol. Chem., 240, PC 4543 (1965).
Nagel, R. L., and Ranney, H. M., Science, 144, 1014 (1964).
Hamaguchi, H., Proc. Jap. Acad., 43, 562 (1967).
Wikler, M., Titani, K., Shinoda, T., and Putnam, F. W., J. Biol. Chem., 242, 1668 (1967).
Putnam, F. W., Titani, K., and Whitley, E., Proc. Roy. Soc., B, 166, 124 (1966).
Gray, W. R., Dreyer, W. J., and Hood, L., Science, 155, 467 (1967).
Hilschmann, N., Hoppe Seyler's Z. Physiol. Chem., 348, 1077 (1967).
Milstein, C., Biochem. J., 101, 352 (1966).
Titani, K., Whitley, E., and Putnam, F. W., Science, 152, 1513 (1966).
Hilschmann, N., and Craig, L. C., Proc. US Nat. Acad. Sci., 53, 1403 (1965).
Fitch, W. M., J. Mol. Biol., 16, 9 (1966).
Muirhead, H., Cox, J. M., Mazzarella, L., and Perutz, M. F., J. Mol. Biol., 28, 117 (1967).
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BLACK, J., DIXON, G. Amino-acid Sequence of Alpha Chains of Human Haptoglobins. Nature 218, 736–741 (1968). https://doi.org/10.1038/218736a0
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DOI: https://doi.org/10.1038/218736a0
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