Abstract
By studying relatives of individuals homozygous for Fanconi's anaemia, a method has been developed for determining the effect of heterozygosity for this gene on susceptibility to cancers.
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References
Heston, W. E., Cancer Res., 25, 1320 (1965).
Lynch, H. T., Hereditary Factors in Carcinoma, 35 (Springer, New York, 1967).
Lynch, H. T., Hereditary Factors in Carcinoma, 125 (Springer, New York, 1967).
Li, F. P., and Fraumeni, J. F., Ann. Intern. Med., 71, 747 (1969).
Crowe, F. W., Schull, W. J., and Neel, J. V., A Clinical, Pathological and Genetic Study of Multiple Neurofibromatosis (Thomas, Springfield, Illinois, 1956).
Nilsson, L. R., Acta Paediat., 49, 518 (1960).
Bloom, G. E., Warner, S., Gerald, P. S., et al., New Eng. J. Med., 274, 8 (1966).
Swift, M. R., and Hirschhorn, K., Ann. Intern. Med., 65, 496 (1966).
Garriga, S., and Crosby, W. H., Blood, 14, 1008 (1959).
Swift, M. R., Zimmerman, D., and McConough, E. R., J. Amer. Med. Assoc. (in the press).
Todaro, G. J., Green, H., and Swift, M. R., Science, 153, 1252 (1966).
World Health Organization, International Classification of Diseases, Manual of the International Statistical Classification of Diseases, Injuries and Causes of Death, Seventh Revision Conference, 1, 357 (1957).
Penrose, L. S., Mackenzie, H. J., and Karn, M. N., Brit. J. Cancer, 2, 168 (1948).
Steinberg, A., Cancer, 13, 985 (1960).
US Department of Health, Education, and Welfare, Public Health Service, National Office of Vital Statistics of the United States, 2, Mortality Statistics (Washington, DC, Government Printing Office, 1932, 1937, 1942, 1947, 1952, 1957, 1962, 1967).
Gunz, F. W., and Veale, A. M. O., J. Nat. Cancer Inst., 42, 517 (1969).
Macklin, M. T., J. Nat. Cancer Inst., 22, 927 (1959).
Macklin, M. T., J. Nat. Cancer Inst., 24, 551 (1960).
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SWIFT, M. Fanconi's Anaemia in the Genetics of Neoplasia. Nature 230, 370–373 (1971). https://doi.org/10.1038/230370a0
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DOI: https://doi.org/10.1038/230370a0
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