Abstract
RETARDED intrauterine growth and low birth weight have been observed in association with congenital defects and foetal infection in humans1–4 and, although animal model systems are available for the study of non-infective factors related to intrauterine growth retardation5–7, the effect of pathogens on this aspect of impaired foetal development has not been the subject of much experimental, investigation. Respiratory virus infection induced by parainfluenza 1 virus in rats causes foetal growth retardation owing to the maternal illness withoutvirus infection of the foetus8. The work described here, however, was carried out to study the effect of maternal infection on foetal growth and development with a virus previously shown to cause foetal infection in mice9–11 without causing overt maternal illness.
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COID, C., RAMSDEN, D. Retardation of Foetal Growth and Plasma Protein Development in Foetuses from Mice injected with Coxsackie B3 Virus. Nature 241, 460–461 (1973). https://doi.org/10.1038/241460a0
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DOI: https://doi.org/10.1038/241460a0
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