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The pathogenesis of cancer metastasis

Nature volume 283, pages 139–146 (1980)Cite this article

Abstract

Metastases do not result from random survival of cells released from the primary tumour but from the selective growth of specialised subpopulations of highly metastatic cells endowed with specific properties that befit them to complete each step of the metastatic process.

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Authors and Affiliations

  1. Department of Experimental Pathology, Roswell Park Memorial Institute, Buffalo, New York, 14263

    George Poste

  2. Cancer Biology Program, National Cancer Institute, Frederick Cancer Research Center, Frederick, Maryland, 21701

    Isaiah J. Fidler

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  1. George Poste
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  2. Isaiah J. Fidler
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Poste, G., Fidler, I. The pathogenesis of cancer metastasis. Nature 283, 139–146 (1980). https://doi.org/10.1038/283139a0

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