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Human metallothionein genes—primary structure of the metallothionein-II gene and a related processed gene

Nature volume 299, pages 797–802 (1982)Cite this article

Abstract

The complete nucleotide sequence of two of the human metallothionein gene family has been compared. One is a functional metallothionein-II gene, the other a pseudogene, lacking introns, terminating in a poly(A) tail and flanked by two direct repeats. In addition, we have detected a size polymorphism associated with the processed gene in the population examined, and we have observed a region of apparent secondary structure homology between a 5′ flanking region of the functional metallothionein-II gene and that of a mouse metallothionein-I gene.

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Authors and Affiliations

  1. Metabolic Research Unit, Department of Medicine, Biochemistry and Biophysics, University of California, San Francisco, California, 94143, USA

    Michael Karin

  2. Center for Recombinant DNA Research and Department of Genetics, Research School of Biological Sciences, Australian National University, Canberra, ACT, 2601, Australia

    Robert I. Richards

  3. Department of Microbiology, University of Southern California School of Medicine, 2025 Zonal Avenue, HMR-401, Los Angeles, California, 90033, USA

    Michael Karin

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  1. Michael Karin
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  2. Robert I. Richards
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Karin, M., Richards, R. Human metallothionein genes—primary structure of the metallothionein-II gene and a related processed gene. Nature 299, 797–802 (1982). https://doi.org/10.1038/299797a0

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  • DOI: https://doi.org/10.1038/299797a0

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