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Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1

Nature volume 303, pages 396–400 (1983)Cite this article

Abstract

A molecular clone containing part of the transforming gene from two human sarcoma cell lines, HT1080 and RD, has been obtained and shown to represent a new member of the human ras gene family. The transforming gene has undergone no major rearrangements and has not been amplified in either sarcoma cell line. The major transcript from the gene is 2,200 nucleotides long and is present at the same levels in both normal fibroblasts and tumour cells. The same gene is also activated in HL60, a promyelocytic leukaemia line and in SK-N-SH, a neuroblastoma line. The gene, N-ras, is located on chromosome 1.

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Authors and Affiliations

  1. Chester Beatty Laboratories, Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK

    Alan Hall, Christopher J. Marshall & Robin A. Weiss

  2. Imperial Cancer Research Fund Laboratories, Lincoln's Inn Fields, London, WC2A 3PX, UK

    Nigel K. Spurr

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  1. Alan Hall
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  2. Christopher J. Marshall
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  3. Nigel K. Spurr
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  4. Robin A. Weiss
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Hall, A., Marshall, C., Spurr, N. et al. Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1. Nature 303, 396–400 (1983). https://doi.org/10.1038/303396a0

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