Abstract
Cellular transforming genes can be detected in human tumours by DNA-mediated transfection into NIH 3T3 mouse fibroblasts1,2. The activated transforming genes have been, in most cases, members of the ras gene family, of which the most frequently found is the c-Ki-ras oncogene3–7 and least frequently the c-Ha-ras gene8–10. An increasing number of studies has identified the presence of activated N-ras (which has no known viral homologue) in human tumour cell lines11–18. Furthermore, other transforming genes, distinct from the ras gene family, have been reported in B-and T-cell lymphomas19,20. The activation of c-Ha-ras and N-ras has been described in some cell lines derived from cases of human malignant melanoma21. Here we describe the presence of transforming activity in the DNA from a human melanoma cell line which shows weak homology with members of the ras oncogene family.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Weinberg, R. A. Adv. Cancer Res. 36, 149–163 (1982).
Cooper, G. M. Science 218, 801–806 (1982).
Der, C. J., Krontiris, T. G. & Cooper, G. M. Proc. natn. Acad. Sci. U.S.A. 79, 3637–3640 (1982).
Pulciani, S. et al. Nature 300, 539–542 (1982).
McCoy, M. S. et al. Nature 302, 79–81 (1983).
Shimizu, K. et al. Proc. natn. Acad. Sci. U.S.A. 80, 2112–2116 (1983).
Cooper, C. S. et al. Cancer Res. 44, 1–10 (1984).
Pulciani, S. et al. Proc. natn. Acad. Sci. U.S.A. 79, 2845–2849 (1982).
Parada, L. F., Tabin, C. J., Shih, C. & Weinberg, R. A. Nature 297, 474–478 (1982).
Santos, E., Tronick, S. R., Aaronson, S. A. Pulciani, S. & Barbacid, B. Nature 298, 343–347 (1982).
Marshall, C. J., Hall, A. & Weiss, R. A. Nature 299, 171–173 (1982).
Shimizu, K., Goldfarb, M., Perucho, M. & Wigler, M. Proc. natn. Acad. Sci. U.S.A. 80, 383–387 (1983).
Murray, M. J. et al. Cell 33, 749–757 (1983).
Hall, A., Marshall, C. J., Spurr, N. K. & Weiss, R. A. Nature 303, 396–400 (1983).
Taparowsky, E., Shimizu, K., Goldfarb, M. & Wigler, M. Cell 34, 581–586 (1983).
Eva, A., Tronick, S. R., Gol, R. Pierce, J. H. & Aaronson, S. A. Proc. natn. Acad. Sci. U.S.A. 80, 4926–4930 (1983).
Souyri, M. & Fleissner, E. Proc. natn. Acad. Sci. U.S.A. 80, 6676–6679 (1983).
Gambke, C., Signer, E. & Moroni, C. Nature 307, 476–478 (1984).
Lane, M., Sainten, A. & Cooper, G. M. Cell 28, 873–880 (1982).
Diamond, A., Cooper, G. M., Ritz, J. & Lane, M. Nature 305, 112–116 (1983).
Albino, A. P., Le Strange, R., Oliff, A. I., Furth, M. & Old, L. J. Nature 308, 69–72 (1984).
Graham, F. L. & Van der Eb, A. J. Virol. 52, 456–461 (1973).
Southern, E. M. J. molec. Biol. 98, 503–517 (1975).
Rubin, C. M., Houck, C. M., Deininger, P. L. & Schmid, C. W. Nature 284, 372–374 (1980).
Ellis, R. W. et al. J. Virol. 36(2), 408–420 (1980).
Ellis, R. W. et al. Nature 292, 506–511 (1981).
Dale, B. & Ozanne, B. Molec. Cell. Biol. 1, 731–742 (1981).
Chang, E. H., Gonda, M. A., Ellis, R. W., Scolnick, E. M. & Lowy, D. R. Proc. natn. Acad. Sci. U.S.A. 79, 4848–4852 (1982).
Wahl, G. M., Stern, M. & Stark, G. R. Proc. natn. Acad. Sci. U.S.A. 76, 3683–3687 (1979).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Padua, R., Barrass, N. & Currie, G. A novel transforming gene in a human malignant melanoma cell line. Nature 311, 671–673 (1984). https://doi.org/10.1038/311671a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/311671a0
This article is cited by
-
Cell death-based treatments of melanoma:conventional treatments and new therapeutic strategies
Cell Death & Disease (2018)
-
Novel Therapies for Metastatic Melanoma: An Update on Their Use in Older Patients
Drugs & Aging (2015)
-
Antitumor effects of the investigational selective MEK inhibitor TAK733 against cutaneous and uveal melanoma cell lines
Molecular Cancer (2012)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
