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Chromosomal localization of the human rhabdomyosarcoma locus by mitotic recombination mapping

Nature volume 329, pages 645–647 (1987)Cite this article

Abstract

A genetic description of the human genome requires maps of three types. The first1 shows the frequency of chromosomal interchange during meiosis, relying on many equally spaced markers2, and is limited to interchanges that do not unmask defects lethal to the conceptus, whose every cell will contain such abnormalities. The second is the physical description of genomic regions defined by karyotypic rearrangements, DNA segments, genes, or their products3. A third description of somatic chromosomal interchanges at mitosis is also required. Because mitotic exchanges occur in a single postembryonic somatic progenitor cell, lethal effects on the organism are reduced. These events have been important in genetic mapping in Drosophila melanogaster4 and fungi5, but they have rarely been detected in mammals6–8. Here we report a significant frequency of mitotic recombination in human tumours and the first application of this information in localizing their predisposing locus.

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References

  1. White, R. L. et al. Nature 313, 101–105 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Botstein, D., White, R. L., Skolnick, M. & Davis, R. W. Am. J. hum. Genet. 32, 314–331 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Shows, T. B., Sakaguchi, A. Y. & Naylor, S. L. Adv. hum. Genet. 12, 341–452 (1982).

    Article  CAS  PubMed  Google Scholar 

  4. Postlethwait, J. H. in Genetics and Biology of Drosophila, Vol. 2c (eds Ashburner, M. & Novitski, E.) 359–343 (Academic, New York, 1978).

    Google Scholar 

  5. Pontecorvo, G. & Kafer, E. Adv. Genet. 9, 71–104 (1958).

    Article  CAS  PubMed  Google Scholar 

  6. Cavenee, W. K. et al. Nature 305, 779–784 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. Wasmuth, J. J. & Hall, L. V. Cell 36, 697–707 (1984).

    Article  CAS  PubMed  Google Scholar 

  8. Raizis, A. M., Becroft, D. M., Shaw, R. L. & Reeve, A. E. Hum. Genet. 70, 344–346 (1985).

    Article  CAS  PubMed  Google Scholar 

  9. Cavenee, W. K. et al. Science 228, 501–503 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  10. Enzinger, F. & Weiss, S., eds in Soft Tissue Tumours 338–378 (Mosby, St Louis, 1983).

  11. Koufos, A. et al. Nature 316, 330–334 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. Hansen, M. et al. Proc. natn. Acad. Sci. U.S.A. 82, 6216–6220 (1985).

    Article  ADS  CAS  Google Scholar 

  13. Glaser, T. et al. Cytogenet. Cell Genet. 40, 643 (1985).

    Google Scholar 

  14. Quan, F., Korneluk, R. G. & Gravel, R. A. Am. J. hum. Genet. 37, A171 (1985).

    Google Scholar 

  15. Höppener, J. et al. Hum. Genet. 66, 309–312 (1984).

    Article  PubMed  Google Scholar 

  16. Schmidtke, J. et al. Hum. Genet. 67, 428–431 (1984).

    Article  CAS  PubMed  Google Scholar 

  17. Antonarakis, S. E., Boehm, C. D., Giardina, P. J. & Kazazian, H. H. Proc. natn. Acad. Sci. U.S.A. 79, 137–141 (1982).

    Article  ADS  CAS  Google Scholar 

  18. Barker, D., Holm, T. & White, R. L. Am. J. hum. Genet. 36, 1159–1171 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Bell, G. I., Karam, J. H. & Rutter, W. J. Proc. natn. Acad. Sci. U.S.A. 78, 5759–5763 (1981).

    Article  ADS  CAS  Google Scholar 

  20. Jansen, M. et al. FEBS Lett. 179, 243–246 (1985).

    Article  CAS  PubMed  Google Scholar 

  21. Goldfarb, M., Shimizu, K., Perucho, M. & Wigler, M. Nature 296, 404–409 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  22. Willard, H. F., Skolnick, M. H., Pearson, P. L. & Mandel, J. L. Cytogenet. Cell Genet. 40, 360–489 (1985)

    Article  CAS  PubMed  Google Scholar 

  23. Waziri, M., Patil, S. R., Hanson, J. W. & Bartley, I. A. J. Pediat. 102, 873–876 (1983).

    Article  CAS  PubMed  Google Scholar 

  24. Turleau, C. et al. Hum. Genet. 67, 219–221 (1984).

    Article  CAS  PubMed  Google Scholar 

  25. Knudson, A. G. & Strong, L. C. J. natn. Cancer Inst. 48, 313–324 (1972).

    Google Scholar 

  26. Riccardi, V. M. et al. Pediatrics 61, 604–610 (1978).

    CAS  PubMed  Google Scholar 

  27. Francke, U. & Riccardi, V. M. Cytogenet. Cell Genet. 24, 185–192 (1979).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Ludwig Institute for Cancer Research, Royal Victoria Hospital, 687 Pine Avenue West, Montréal, Québec, H3A 1A1, Canada

    H. J. Scrable & W. K. Cavenee

  2. Division of Pathology, Children's Hospital Medical Center, Elland and Bethesda Avenues, Cincinnati, Ohio, 45229, USA

    D. P. Witte

  3. Division of Hematology/Oncology, Children's Hospital Medical Center, Elland and Bethesda Avenues, Cincinnati, Ohio, 45229, USA

    B. C. Lampkin

Authors
  1. H. J. Scrable
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  2. D. P. Witte
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  3. B. C. Lampkin
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  4. W. K. Cavenee
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Scrable, H., Witte, D., Lampkin, B. et al. Chromosomal localization of the human rhabdomyosarcoma locus by mitotic recombination mapping. Nature 329, 645–647 (1987). https://doi.org/10.1038/329645a0

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