Abstract
THE cross-linkage of high affinity Fcε receptors (FcεRI) on mast cells and basophils is central to the induction of allergic inflammatory responses. As a result of such cross-linkage, mast cells secrete a variety of preformed biologically active substances, such as histamine, and newly synthesized arachidonic acid metabolites1. Here we show that cross-linkage of FcεRI on a series of non-transformed murine mast cell lines, or treatment of these cells with calcium ionophores, stimulates increased messenger RNA levels and secretion of a group of lymphokines classically produced by a subset of murine T cell lines (TH2cells)2. These factors include interleukin-3 (a mast cell growth factor)s interleukin-4 (an IgE 'switch factor'), interleukin-5 (an eosinophil differentiation factor) and interleukin-6 (a factor controlling immunoglobulin secretion). The production of these polypeptide factors by mast cells may have great importance in the induction of allergic and anti-parasite inflammatory responses.
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Plaut, M., Pierce, J., Watson, C. et al. Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores. Nature 339, 64–67 (1989). https://doi.org/10.1038/339064a0
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DOI: https://doi.org/10.1038/339064a0
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