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GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours

Nature volume 340, pages 692–696 (1989)Cite this article

Abstract

A subset of growth hormone-secreting human pituitary tumours carries somatic mutations that inhibit GTPase activity of a G protein α chain, αs. The resulting activation of adenylyl cyclase bypasses the cells' normal requirement for trophic hormone. Amino acids substituted in the putative gsp oncogene identify a domain of G protein α-chains required for intrinsic ability to hydrolyse GTP. This domain may serve as a built-in counter-part of the separate GTPase-activating proteins required for GTP hydrolysis by small GTP-binding proteins such as p21ras.

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Authors and Affiliations

  1. Departments of Pharmacology and Medicine and the Cardiovascular Research Institute, University of California, San Francisco, California, 94143, USA

    Claudia A. Landis, Susan B. Masters, Ann M. Pace & Henry R. Bourne

  2. University of California, San Francisco, California, 94143, USA

    Claudia A. Landis, Susan B. Masters, Ann M. Pace & Henry R. Bourne

  3. Renal Division, Department of Medicine, University of California, San Francisco, California, 94143, USA

    Claudia A. Landis

  4. Department of Endocrinology, School of Medicine, University of Milan, Italy

    Anna Spada

  5. Department of Pharmacology, CNR Center of Cytopharmacology, Scientific Institute San Raffaele, University of Milan, Italy

    Lucia Vallar

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  1. Claudia A. Landis
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Landis, C., Masters, S., Spada, A. et al. GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature 340, 692–696 (1989). https://doi.org/10.1038/340692a0

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