Abstract
ALTHOUGH acute, millisecond-to-millisecond actions of neurotransinitters are well documented, diverse longer-term effects have been discovered only recently1–5. Emerging evidence indicates that these signals regulate a variety of neuronal processes, from phenotypic expression to neurite outgrowth6–19. Here we show that a single putative transmitter, vasoactive intestinal peptide, can exert multiple, long-term effects simultaneously: it stimulates mitosis, promotes neurite outgrowth and enhances survival of sympathetic neuron precursors in culture. As the peptide seems to be a normal presynaptic transmitter in the sympathetic system19–25, synaptic transmission may exert hitherto unexpected effects.
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Pincus, D., DiCicco-Bloom, E. & Black, I. Vasoactive intestinal peptide regulates mitosis, differentiation and survival of cultured sympathetic neuroblasts. Nature 343, 564–567 (1990). https://doi.org/10.1038/343564a0
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DOI: https://doi.org/10.1038/343564a0
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