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Crystal structure of a complex between interferon-γ and its soluble high-affinity receptor

Abstract

The crystal structure of interferon-γ bound to the extracellular fragment of its high-affinity cellsurface receptor reveals the first view of a class-2 cytokine receptor-ligand complex. In the complex, one interferon-γ homodimer binds two receptor molecules. Unlike the class-1 growth hormone receptor complex, the two interferon-γ receptors do not interact with one another and are separated by 27 Ã. Upon receptor binding, the flexible AB loop of interferon-γ undergoes a conformational change that includes the formation of a 310 helix.

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Walter, M., Windsor, W., Nagabhushan, T. et al. Crystal structure of a complex between interferon-γ and its soluble high-affinity receptor. Nature 376, 230–235 (1995). https://doi.org/10.1038/376230a0

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